| Effects of exercise training intensity on pancreatic beta-cell function. | |
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MedLine Citation:
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PMID: 19592624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. Exercise training improves insulin sensitivity, but its effects on beta-cell function are less well studied. RESEARCH DESIGN AND METHODS: Sedentary, overweight adults were randomized to control or one of three 8-month exercise programs: 1) low amount/moderate intensity, 2) low amount/vigorous intensity, or 3) high amount/vigorous intensity. Of 387 randomized, 260 completed the study and 237 had complete data. Insulin sensitivity (S(i)), acute insulin response to glucose (AIRg), and the disposition index (DI = S(i) x AIRg) were modeled from an intravenous glucose tolerance test. RESULTS: Compared with control subjects, all three training programs led to increases in DI. However, the moderate-intensity group experienced a significantly larger increase in DI than either of the vigorous-intensity groups and through a different mechanism. The high-amount/vigorous-intensity group improved S(i) and had a compensatory reduction in AIRg, whereas the moderate-intensity group had a similar improvement in S(i) but almost no reduction in AIRg. Importantly, the inactive control group experienced a significant increase in fasting glucose. CONCLUSIONS: To the extent that the DI accurately reflects beta-cell function, we observed that both moderate- and vigorous-intensity exercise training improved beta-cell function, albeit through distinct mechanisms. It is not clear which of these mechanisms is preferable for maintenance of metabolic health. While moderate-intensity exercise led to a larger improvement in DI, which may reflect a transition toward a more normal DI, longer-term investigations would be necessary to determine which was more effective at reducing diabetes risk. |
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Authors:
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Cris A Slentz; Charles J Tanner; Lori A Bateman; Michael T Durheim; Kim M Huffman; Joseph A Houmard; William E Kraus |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2009-07-10 |
Journal Detail:
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Title: Diabetes care Volume: 32 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-01 Completed Date: 2009-12-29 Revised Date: 2010-10-04 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1807-11 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA. cris.slentz@duke.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00200993 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Exercise / physiology* Female Glucose Tolerance Test Humans Insulin Resistance / physiology Insulin-Secreting Cells / metabolism, physiology* Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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HL-57354/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Diabetes Care. 2010 Mar;33(3):e45
[PMID:
20190293
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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