Document Detail


Effects of exercise training intensity on pancreatic beta-cell function.
MedLine Citation:
PMID:  19592624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. Exercise training improves insulin sensitivity, but its effects on beta-cell function are less well studied.
RESEARCH DESIGN AND METHODS: Sedentary, overweight adults were randomized to control or one of three 8-month exercise programs: 1) low amount/moderate intensity, 2) low amount/vigorous intensity, or 3) high amount/vigorous intensity. Of 387 randomized, 260 completed the study and 237 had complete data. Insulin sensitivity (S(i)), acute insulin response to glucose (AIRg), and the disposition index (DI = S(i) x AIRg) were modeled from an intravenous glucose tolerance test.
RESULTS: Compared with control subjects, all three training programs led to increases in DI. However, the moderate-intensity group experienced a significantly larger increase in DI than either of the vigorous-intensity groups and through a different mechanism. The high-amount/vigorous-intensity group improved S(i) and had a compensatory reduction in AIRg, whereas the moderate-intensity group had a similar improvement in S(i) but almost no reduction in AIRg. Importantly, the inactive control group experienced a significant increase in fasting glucose.
CONCLUSIONS: To the extent that the DI accurately reflects beta-cell function, we observed that both moderate- and vigorous-intensity exercise training improved beta-cell function, albeit through distinct mechanisms. It is not clear which of these mechanisms is preferable for maintenance of metabolic health. While moderate-intensity exercise led to a larger improvement in DI, which may reflect a transition toward a more normal DI, longer-term investigations would be necessary to determine which was more effective at reducing diabetes risk.
Authors:
Cris A Slentz; Charles J Tanner; Lori A Bateman; Michael T Durheim; Kim M Huffman; Joseph A Houmard; William E Kraus
Related Documents :
19864294 - Enhanced insulin sensitivity after acute exercise is not associated with changes in hig...
11334434 - Amp-activated protein kinase (ampk) is activated in muscle of subjects with type 2 diab...
17296514 - Substrate oxidation during exercise: type 2 diabetes is associated with a decrease in l...
1860814 - Methylamine metabolism in hansenula polymorpha: an in vivo 13c and 31p nuclear magnetic...
19672044 - The potential anti-inflammatory effect of exercise in chronic obstructive pulmonary dis...
21606874 - Exercise, amino acids, and aging in the control of human muscle protein synthesis.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-07-10
Journal Detail:
Title:  Diabetes care     Volume:  32     ISSN:  1935-5548     ISO Abbreviation:  Diabetes Care     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-01     Completed Date:  2009-12-29     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1807-11     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA. cris.slentz@duke.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00200993
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Exercise / physiology*
Female
Glucose Tolerance Test
Humans
Insulin Resistance / physiology
Insulin-Secreting Cells / metabolism,  physiology*
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
HL-57354/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Diabetes Care. 2010 Mar;33(3):e45   [PMID:  20190293 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabete...
Next Document:  Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized con...