| Effects of exercise training on the distribution of metallic mercury in mice. | |
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MedLine Citation:
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PMID: 7946505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The purpose of this study was to correlate exercise induced changes of antioxidant enzymes with the distribution of mercury after mercury vapour exposure in mice. 2. Exercise training consisted of swimming (1 h/day for 5 days/week) for 9 weeks. After 9 weeks of training, swim-trained mice showed significantly elevated levels of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSHpx) in their red blood cells, CAT and GSHpx in their kidneys and SOD in the liver. 3. Exercised mice (Ex) and non-exercised mice (N.Ex) were exposed to mercury vapour (3.5 mg m-3) for 1 h. Mercury concentrations were assayed in the blood, brain, heart, lungs, liver and kidneys along with the mercury content of the entire body. The whole body mercury content showed no significant difference in any measurement (immediately, 24 h and 48 h after mercury exposure) between the Ex and N.Ex groups. Mercury concentrations in the Ex group were significantly higher than the N.Ex group in the heart, whole blood, red blood cells and the brain at 24 and 48 h; and in the plasma and kidneys at 24 h. 4. It was concluded that exercise training is a factor in distribution changes of mercury after exposure to mercury vapour, though it is not a factor in the total absorption and excretion of mercury. |
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Authors:
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N Shimojo; Y Arai |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Human & experimental toxicology Volume: 13 ISSN: 0960-3271 ISO Abbreviation: Hum Exp Toxicol Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-12-15 Completed Date: 1994-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 524-8 Citation Subset: IM |
Affiliation:
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Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Analysis of Variance Animals Brain / enzymology, metabolism Catalase / blood*, metabolism Erythrocytes / enzymology Glutathione Peroxidase / blood*, metabolism Kidney / enzymology, metabolism Liver / enzymology, metabolism Lung / enzymology, metabolism Male Mercury / metabolism*, pharmacokinetics Mice Myocardium / metabolism Physical Conditioning, Animal / physiology* Random Allocation Superoxide Dismutase / blood*, metabolism Swimming Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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7439-97-6/Mercury; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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