Document Detail

Effects of exercise training on calf tissue oxygenation in men with intermittent claudication.
MedLine Citation:
PMID:  19854422     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of exercise training on calf tissue oxygenation in men with peripheral arterial disease and intermittent calf claudication. DESIGN: This pilot study was prospective and longitudinal and used a one-group, pretest-posttest design. SETTING: Tertiary care medical center for veterans. PARTICIPANTS: Fifteen male veterans (mean age 69 years) with Fontaine stage IIa peripheral arterial disease and classic intermittent claudication. MAIN OUTCOME MEASUREMENTS: Before and after intervention, participants performed graded treadmill exercise tests while medial calf tissue oxygenation (StO(2), % oxyhemoglobin saturation) was monitored continuously with near-infrared spectroscopy. INTERVENTION: The intervention consisted of a 3-month exercise training program involving 3 sessions per week at the clinic (treadmill walking, calf ergometry) and 2 sessions per week at home (free walking, standing heel raises). RESULTS: After completion of the intervention, participants significantly increased their maximal treadmill exercise time from 7.19 to 11.27 minutes. Mean exercise StO(2) decreased from 29% to 19% saturation, StO(2) x time area increased from 421% * min to 730% * min StO(2) nadir, and StO(2) recovery time did not change significantly. CONCLUSIONS: After the exercise intervention, the improved treadmill walking performance was accompanied by greater calf tissue deoxygenation during exercise. Given the continued presence of ischemia, this finding may represent increased capillarization and diffusion-based enhancement of arteriovenous O(2) extraction.
Stephen F Figoni; Charles F Kunkel; A M Erika Scremin; Arash Asher; Norman L Banks; Anthony Rivera; John K Tin; Babak Cohen
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  PM & R : the journal of injury, function, and rehabilitation     Volume:  1     ISSN:  1934-1482     ISO Abbreviation:  PM R     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101491319     Medline TA:  PM R     Country:  United States    
Other Details:
Languages:  eng     Pagination:  932-40     Citation Subset:  IM    
Physical Medicine and Rehabilitation Service, VA Greater Los Angeles Healthcare System, VA West Los Angeles Healthcare Center, Los Angeles, CA, USA.
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MeSH Terms
Capillaries / physiopathology
Exercise Test
Exercise Therapy*
Intermittent Claudication / physiopathology*,  therapy
Leg / blood supply*
Oxygen / metabolism
Peripheral Vascular Diseases / physiopathology,  therapy*
Prospective Studies
Spectroscopy, Near-Infrared
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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