| Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts. | |
| | |
MedLine Citation:
|
PMID: 16166449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients undergoing adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents. EXPERIMENTAL DESIGN: Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups (n = 21 per group): (a) control, (b) exercise-only, (c) doxorubicin-only, or (d) exercise + doxorubicin. Exercise groups performed progressive treadmill running up to 18 m/min at 0% grade for 45 minutes, 5 d/wk for 8 weeks. RESULTS: Tumor growth delay was significantly longer in the doxorubicin-only and exercise + doxorubicin groups compared with the control (median 42 versus 25 days, P = 0.0082; 36 versus 25 days, P = 0.029, respectively) and exercise-only groups (median 42 versus 25 days, P = 0.029; 36 versus 25 days, P = 0.080, respectively). There was no significant difference between the doxorubicin-only and exercise + doxorubicin groups (median 42 versus 36 days, P = 0.33), suggesting that moderate intensity exercise does not significantly influence doxorubicin-induced tumor growth delay. CONCLUSION: These studies are essential to fully understand the safety and application of exercise as a supportive intervention in cancer control. |
| | |
Authors:
|
Lee W Jones; Neil D Eves; Kerry S Courneya; Brian K Chiu; Vickie E Baracos; John Hanson; Lorelei Johnson; John R Mackey |
Related Documents
:
|
2587289 - Effects of aerobic interval training on cancer patients' functional capacity. 2812979 - Relationship between ratings of perceived exertion and exercise-induced decrease in sta... 14649629 - Effects of command and control vehicle (c2v) operational environment on soldier health ... 16177619 - Do current sports brassiere designs impede respiratory function? 20607139 - Group vs. individual exercise interventions for women with breast cancer: a meta-analysis. 7870559 - Comparative effects of exercise reduction and relaxation training on mood states and ty... 19246179 - Evaluation of a fatigue initiative: information on exercise for patients receiving canc... 8513429 - Maximal short-term exercise performance and ion regulation in cystic fibrosis. 12492249 - Aerobic and neuromuscular performance capacity of physically active females with early ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 11 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-09-16 Completed Date: 2005-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: United States |
Other Details:
|
Languages: eng Pagination: 6695-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA. lee.w.jones@duke.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibiotics, Antineoplastic / therapeutic use* Body Weight / drug effects, physiology Breast Neoplasms / pathology, therapy Cell Line, Tumor Doxorubicin / therapeutic use* Female Humans Mammary Neoplasms, Experimental / therapy* Mice Mice, Nude Physical Conditioning, Animal / physiology* Random Allocation Survival Analysis Time Factors Xenograft Model Antitumor Assays / methods |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular car...
Next Document: Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes.