Document Detail


Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts.
MedLine Citation:
PMID:  16166449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients undergoing adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents. EXPERIMENTAL DESIGN: Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups (n = 21 per group): (a) control, (b) exercise-only, (c) doxorubicin-only, or (d) exercise + doxorubicin. Exercise groups performed progressive treadmill running up to 18 m/min at 0% grade for 45 minutes, 5 d/wk for 8 weeks. RESULTS: Tumor growth delay was significantly longer in the doxorubicin-only and exercise + doxorubicin groups compared with the control (median 42 versus 25 days, P = 0.0082; 36 versus 25 days, P = 0.029, respectively) and exercise-only groups (median 42 versus 25 days, P = 0.029; 36 versus 25 days, P = 0.080, respectively). There was no significant difference between the doxorubicin-only and exercise + doxorubicin groups (median 42 versus 36 days, P = 0.33), suggesting that moderate intensity exercise does not significantly influence doxorubicin-induced tumor growth delay. CONCLUSION: These studies are essential to fully understand the safety and application of exercise as a supportive intervention in cancer control.
Authors:
Lee W Jones; Neil D Eves; Kerry S Courneya; Brian K Chiu; Vickie E Baracos; John Hanson; Lorelei Johnson; John R Mackey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  11     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-16     Completed Date:  2005-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6695-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA. lee.w.jones@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibiotics, Antineoplastic / therapeutic use*
Body Weight / drug effects,  physiology
Breast Neoplasms / pathology,  therapy
Cell Line, Tumor
Doxorubicin / therapeutic use*
Female
Humans
Mammary Neoplasms, Experimental / therapy*
Mice
Mice, Nude
Physical Conditioning, Animal / physiology*
Random Allocation
Survival Analysis
Time Factors
Xenograft Model Antitumor Assays / methods
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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