Document Detail


Effects of exercise training on airway responsiveness and airway cells in healthy subjects.
MedLine Citation:
PMID:  20538849     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Airway responsiveness to methacholine (Mch) in the absence of deep inspirations (DIs) is lower in athletes compared with sedentary individuals. In this prospective study, we tested the hypothesis that a training exercise program reduces the bronchoconstrictive effect of Mch. Ten healthy sedentary subjects (M/F: 3/7; mean + or - SD age: 22 + or - 3 yr) entered a 10-wk indoor rowing exercise program on rowing ergometer and underwent Mch bronchoprovocation in the absence of DIs at baseline, at weeks 5 and 10, as well as 4-6 wk after the training program was completed. Exercise-induced changes on airway cells and markers of airway inflammation were also assessed by sputum induction and venous blood samples. Mean power output during the 1,000 m test was 169 + or - 49 W/stroke at baseline, 174 + or - 49 W/stroke at 5 wk, and 200 + or - 60 W/stroke at 10 wk of training (P < 0.05). The median Mch dose used at baseline was 50 mg/ml (range 25-75 mg/ml) and remained constant per study design. At the pretraining evaluation, the percent reduction in the primary outcome, the inspiratory vital capacity (IVC) after inhalation of Mch in the absence of DIs was 31 +/- 13%; at week 5, the Mch-induced reduction in IVC was 22 + or - 19%, P = 0.01, and it further decreased to 15 + or - 11% at week 10 (P = 0.0008). The percent fall in IVC 4-6 wk after the end of training was 15 + or - 11% (P = 0.87 vs. end of training). Changes in airway cells were not associated with changes in airway responsiveness. Our data show that a course of exercise training can attenuate airway responsiveness against Mch inhaled in the absence of DIs in healthy subjects and suggest that a sedentary lifestyle may favor development of airways hyperresponsiveness.
Authors:
Nicola Scichilone; Giuseppe Morici; Daniele Zangla; Laura Chimenti; Eva Davì; Simona Reitano; Alessandra Paternò; Roberta Santagata; Alkis Togias; Vincenzo Bellia; Maria Rosaria Bonsignore
Related Documents :
12235039 - Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects.
9187169 - Detection of small airway dysfunction using specific airway conductance.
2221589 - The effect of repetitive exercise on airway temperatures.
3180669 - Ventilatory function during urography: a comparison of iopamidol and sodium iothalamate.
3169109 - Duration of protection of calcium channel blockers against exercise-induced bronchospas...
1604059 - Chemoreceptor control of the airways.
11001349 - Core temperature measurement during supine exercise: esophageal, rectal, and intestinal...
10702909 - Treatment of recycled kraft pulps with trichoderma reesei hemicellulases and cellulases.
23866909 - Regular exercise is the most significant lifestyle parameter associated with the severi...
Publication Detail:
Type:  Journal Article     Date:  2010-06-10
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-94     Citation Subset:  IM    
Affiliation:
Dept. of Internal Medicine, Div. of Pulmonology (DIBIMIS Univ. of Palermo, "Villa Sofia-Cervello" Hospital, Via Trabucco 180, 90146 Palermo, Italy. n.scichilone@libero.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections
Comment In:
J Appl Physiol. 2010 Aug;109(2):267-8   [PMID:  20522737 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neonatal total liquid ventilation: is low-frequency forced oscillation technique suitable for respir...
Next Document:  An adjuvant for the induction of potent, protective humoral responses to an H5N1 influenza virus vac...