Document Detail

Effects of exercise on respiratory flow and sputum properties in patients with cystic fibrosis.
MedLine Citation:
PMID:  20829339     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The physiologic mechanisms by which exercise may clear secretions in subjects with cystic fibrosis (CF) are unknown. The purpose of this study was to compare ventilation, respiratory flow, and sputum properties following treadmill and cycle exercise with resting breathing (referred to as "control").
METHODS: In 14 adult subjects with CF, ventilation and respiratory flow were measured during 20 min of resting breathing, treadmill exercise, and cycle exercise in a 3-day crossover study. Treadmill and cycle exercise were performed at the work rate equivalent to 60% of the subject's peak oxygen uptake. Ease of expectoration and sputum properties (solids content and mechanical impedance) were measured before and immediately after the interventions and after 20-min recovery.
RESULTS: Ease of expectoration improved following exercise. Ventilation and respiratory flow were significantly higher during treadmill and cycle exercise compared with control. Sputum solids content did not change following treadmill or cycle exercise. There was a significantly greater decrease in sputum mechanical impedance following treadmill exercise compared with control, but no significant decrease in sputum mechanical impedance following cycle exercise compared with control.
CONCLUSIONS: The improvement in ease of expectoration following exercise may have been due to the higher ventilation and respiratory flow. The reductions in sputum mechanical impedance with treadmill exercise may have been due to the trunk oscillations associated with walking.
TRIAL REGISTRY: Australian and New Zealand Clinical Trials Registry; No. 12605000422628; URL:
Tiffany J Dwyer; Jennifer A Alison; Zoe J McKeough; Evangelia Daviskas; Peter T P Bye
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-09-09
Journal Detail:
Title:  Chest     Volume:  139     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-06     Completed Date:  2011-06-07     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  870-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cross-Over Studies
Cystic Fibrosis / metabolism,  physiopathology,  rehabilitation*
Exercise / physiology*
Exercise Therapy / methods*
Forced Expiratory Flow Rates / physiology*
Sputum / metabolism*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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