|Effects of exercise rehabilitation on cardiovascular risk factors in older patients with peripheral arterial occlusive disease.|
|PMID: 10753274 Owner: NLM Status: MEDLINE|
|OBJECTIVE: The purpose of this study was to determine whether a 6-month exercise rehabilitation program can improve cardiovascular risk factors in patients with peripheral arterial occlusive disease (PAOD).
METHODS: Thirty-four patients (mean age, 68 +/- 8 years; range 54-84 years) with PAOD with intermittent claudication (Fontaine stage II) and 14 longitudinal controls of comparable age with stage II PAOD enrolled in an exercise intervention at the University Medical Center and Veterans Affairs Medical Center at Baltimore, Maryland. The main outcome measures were lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol [LDL-C]), fasting glucose, blood pressure, body mass index, treadmill times to onset and maximal claudication pain, cardiopulmonary function (peak oxygen uptake), and ankle/brachial index.
RESULTS: With exercise rehabilitation, treadmill times to onset and maximal claudication pain increased by 106% and 64% (P <.0001), whereas peak oxygen uptake increased 7% (P <.05). Exercise rehabilitation lowered total cholesterol and LDL-C levels by 5.2% (P <.005) and 8% (P <.01), respectively. Systolic blood pressure declined by 5.7% (P <.05) with no change in diastolic blood pressure. These changes in cholesterol and LDL-C concentrations were related to their initial values. All other cardiovascular risk factors measured did not change. There was no correlation between improvement of cardiovascular risk factors and functional performance measurements. None of the variables measured changed significantly in the control group.
CONCLUSIONS: Exercise rehabilitation not only improves functional performance, but also results in favorable alterations in cardiovascular risk factor profile, which is an important element in the management of PAOD.
|A M Izquierdo-Porrera; A W Gardner; C C Powell; L I Katzel|
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|Type: Journal Article|
|Title: Journal of vascular surgery Volume: 31 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2000 Apr|
|Created Date: 2000-05-02 Completed Date: 2000-05-02 Revised Date: 2012-10-03|
Medline Journal Info:
|Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES|
|Languages: eng Pagination: 670-7 Citation Subset: IM|
|Claude D. Pepper Older Americans Independence Center (OAIC), Department of Medicine, Division of Gerontology, University of Maryland, USA.|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Ankle / blood supply
Arterial Occlusive Diseases / physiopathology, rehabilitation*
Blood Glucose / analysis
Blood Pressure / physiology
Body Mass Index
Brachial Artery / physiology
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Heart Diseases / blood, etiology*
Intermittent Claudication / physiopathology, rehabilitation
Oxygen Consumption / physiology
Peripheral Vascular Diseases / physiopathology, rehabilitation*
Triglycerides / blood
|0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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