Document Detail

Effects of exercise rehabilitation on cardiovascular risk factors in older patients with peripheral arterial occlusive disease.
MedLine Citation:
PMID:  10753274     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine whether a 6-month exercise rehabilitation program can improve cardiovascular risk factors in patients with peripheral arterial occlusive disease (PAOD).
METHODS: Thirty-four patients (mean age, 68 +/- 8 years; range 54-84 years) with PAOD with intermittent claudication (Fontaine stage II) and 14 longitudinal controls of comparable age with stage II PAOD enrolled in an exercise intervention at the University Medical Center and Veterans Affairs Medical Center at Baltimore, Maryland. The main outcome measures were lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol [LDL-C]), fasting glucose, blood pressure, body mass index, treadmill times to onset and maximal claudication pain, cardiopulmonary function (peak oxygen uptake), and ankle/brachial index.
RESULTS: With exercise rehabilitation, treadmill times to onset and maximal claudication pain increased by 106% and 64% (P <.0001), whereas peak oxygen uptake increased 7% (P <.05). Exercise rehabilitation lowered total cholesterol and LDL-C levels by 5.2% (P <.005) and 8% (P <.01), respectively. Systolic blood pressure declined by 5.7% (P <.05) with no change in diastolic blood pressure. These changes in cholesterol and LDL-C concentrations were related to their initial values. All other cardiovascular risk factors measured did not change. There was no correlation between improvement of cardiovascular risk factors and functional performance measurements. None of the variables measured changed significantly in the control group.
CONCLUSIONS: Exercise rehabilitation not only improves functional performance, but also results in favorable alterations in cardiovascular risk factor profile, which is an important element in the management of PAOD.
A M Izquierdo-Porrera; A W Gardner; C C Powell; L I Katzel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  31     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-02     Completed Date:  2000-05-02     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  670-7     Citation Subset:  IM    
Claude D. Pepper Older Americans Independence Center (OAIC), Department of Medicine, Division of Gerontology, University of Maryland, USA.
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MeSH Terms
Aged, 80 and over
Ankle / blood supply
Arterial Occlusive Diseases / physiopathology,  rehabilitation*
Blood Glucose / analysis
Blood Pressure / physiology
Body Mass Index
Brachial Artery / physiology
Case-Control Studies
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Exercise Test
Exercise Therapy*
Heart Diseases / blood,  etiology*
Intermittent Claudication / physiopathology,  rehabilitation
Longitudinal Studies
Middle Aged
Oxygen Consumption / physiology
Peripheral Vascular Diseases / physiopathology,  rehabilitation*
Risk Factors
Time Factors
Treatment Outcome
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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