| Effects of exercise and nitrates on blood flow in internal mammary artery to coronary artery grafts: a non-invasive study. | |
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MedLine Citation:
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PMID: 7634746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The aim of the present study was to investigate the effects of exercise and of sublingual glyceryl trinitrate on the pattern of blood flow, as studied by Doppler ultrasound, in internal mammary artery grafts performed to relieve severe stenosis of the left anterior descending coronary artery. The accessibility of the graft to transcutaneous ultrasound examination allows the effects of exercise and nitrate administration on coronary blood flow to be studied non-invasively. 2. Angina-free patients with left internal mammary to left anterior descending coronary artery grafts were studied using transcutaneous duplex ultrasound at rest, after leg exercise and after sublingual administration of 0.5 mg or 1 mg of glyceryl trinitrate. 3. Resting graft blood flow showed a biphasic pattern, with forward flow in both systole and diastole. Exercise caused an increase in time-averaged velocity of graft blood flow from 17.3 (3.3) to 24.0 (7.2) cm/s (P = 0.001), and of calculated volume flow from 44.7 (3.08) to 59.8 (5.89) ml/min (P = 0.002). Diastolic peak velocity increased from 36.1 (9.9) cm/s to 46.8 (16.2) cm/s (P = 0.04), while peak systolic velocity was unchanged. Nitrate administration caused a fall in systolic and diastolic blood pressure and an increase in heart rate; graft flow was maintained [time-averaged velocity 18.3 (6.2) cm/s before and 16.7 (5.7) cm/s after 500 micrograms of glyceryl trinitrate], but systole was shortened and the proportion of blood flow in diastole increased [systolic/diastolic flow ratio 0.558 (0.139) before and 0.374 (0.156) after 500 micrograms of glyceryl trinitrate, P = 0.01].(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Mauric; N J Samani; D P de Bono |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 88 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-09-11 Completed Date: 1995-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 635-41 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Leicester, Glenfield Hospital, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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surgery Coronary Vessels / ultrasonography Exercise Test Female Humans Internal Mammary-Coronary Artery Anastomosis* Male Middle Aged Nitroglycerin / pharmacology* Regional Blood Flow / drug effects Ultrasonography, Doppler |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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