Document Detail


Effects of exercise on lymphocytes and cytokines.
MedLine Citation:
PMID:  10953894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To review results on exercise induced changes in the immune system following strenuous and moderate exercise. METHODS: A literature search over the past 15 years was conducted using Medline and selected papers. RESULTS: After intense long term exercise, the immune system is characterised by concomitant impairment of the cellular immune system and increased inflammation. Thus low concentrations of lymphocytes, suppressed natural immunity, suppressed lymphocyte proliferation, and suppressed levels of secretory IgA in saliva are found simultaneously with high levels of circulating proinflammatory and antiinflammatory cytokines. The underlying mechanisms are multifactorial and include neuroendocrinological and metabolic factors. The clinical consequences of the exercise induced immune changes have not formally been identified, but the exercise effect on lymphocyte dynamics and immune function may be linked to the exercise effects on resistance to infections and malignancy and the cytokine response may be linked to muscle damage or muscle cell growth. CONCLUSIONS: Moderate exercise across the life span seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function. It is premature to offer advice on nutrition to athletes in order to alter the exercise induced immunosuppression found after exercise.
Authors:
B K Pedersen; A D Toft
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of sports medicine     Volume:  34     ISSN:  0306-3674     ISO Abbreviation:  Br J Sports Med     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-12-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Affiliation:
The Copenhagen Muscle Research Centre and Department of Infectious Diseases Rigshospitalet, University of Copenhagen, Denmark. bkp@rh.dk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / analysis*,  immunology
Exercise / physiology*
Fatty Acids, Unsaturated / pharmacology
Glutamine / physiology
Humans
Lymphocytes / immunology,  physiology*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Fatty Acids, Unsaturated; 56-85-9/Glutamine
Comments/Corrections

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