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EFFECTS OF EXERCISE INTERVENTIONS IN GRAFT VERSUS HOST DISEASE MODELS.
MedLine Citation:
PMID:  23127525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Graft-versus-host-disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is associated with high morbimortality and decreased patients' physical capacity. We evaluated the effects of an 11-week moderate-intensity exercise (treadmill) training program performed after allo-HSCT in a murine acute (aGVHD) and chronic GVHD model (cGVHD). Female mice (aged 8-12 weeks) were randomly assigned to an exercise or control group. They completed a maximal treadmill test before allo-HSCT (with donor bone marrow cells and splenocytes) and after the 11-week period, during which we evaluated clinical severity scores and survival (Kaplan-Meier method). Before allo-HSCT, and at days +21, +52 and +83 (upon sacrifice), we collected blood samples for immune cell reconstitution and cytokine analysis. The main results were: (i) in aGVHD, exercise improved maximal physical capacity over the 11-week period compared with preallo- HSCT conditions (p<0.001 for the between-group comparison) and benefited total clinical score evolution (p=0.05 for the group x time interaction effect), without altering immune reconstitution; (ii) in cGVHD, exercise training resulted in a lesser deterioration of physical capacity after 11 weeks (p=0.023). Our results highlight the potential beneficial effects of exercise as coadjuvant intervention against GVHD, especially in the acute form of the disease.
Authors:
Carmen Fiuza-Luces; Africa González-Murillo; Luisa Soares-Miranda; Jesús Martínez Palacio; Isabel Colmenero; Fernando Casco; Gustavo Melén; María Morán; Alejandro Lucía; Manuel Ramírez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-31
Journal Detail:
Title:  Cell transplantation     Volume:  -     ISSN:  1555-3892     ISO Abbreviation:  Cell Transplant     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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