Document Detail

MedLine Citation:
PMID:  23127525     Owner:  NLM     Status:  Publisher    
Graft-versus-host-disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is associated with high morbimortality and decreased patients' physical capacity. We evaluated the effects of an 11-week moderate-intensity exercise (treadmill) training program performed after allo-HSCT in a murine acute (aGVHD) and chronic GVHD model (cGVHD). Female mice (aged 8-12 weeks) were randomly assigned to an exercise or control group. They completed a maximal treadmill test before allo-HSCT (with donor bone marrow cells and splenocytes) and after the 11-week period, during which we evaluated clinical severity scores and survival (Kaplan-Meier method). Before allo-HSCT, and at days +21, +52 and +83 (upon sacrifice), we collected blood samples for immune cell reconstitution and cytokine analysis. The main results were: (i) in aGVHD, exercise improved maximal physical capacity over the 11-week period compared with preallo- HSCT conditions (p<0.001 for the between-group comparison) and benefited total clinical score evolution (p=0.05 for the group x time interaction effect), without altering immune reconstitution; (ii) in cGVHD, exercise training resulted in a lesser deterioration of physical capacity after 11 weeks (p=0.023). Our results highlight the potential beneficial effects of exercise as coadjuvant intervention against GVHD, especially in the acute form of the disease.
Carmen Fiuza-Luces; Africa González-Murillo; Luisa Soares-Miranda; Jesús Martínez Palacio; Isabel Colmenero; Fernando Casco; Gustavo Melén; María Morán; Alejandro Lucía; Manuel Ramírez
Related Documents :
23258605 - Exercise improves the th1 response by modulating cytokine and no production in balb/c m...
22734915 - Effects of low-intensity, elastic band resistance exercise combined with blood flow res...
6204165 - High salt intake blunts plasma catecholamine and renin responses to exercise: less supp...
15757125 - Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose conc...
12741875 - Effect of a submaximal half-squats warm-up program on vertical jumping ability.
3521335 - Adrenergic influence on hormonal and hepatic metabolic response to exercise in rats.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-31
Journal Detail:
Title:  Cell transplantation     Volume:  -     ISSN:  1555-3892     ISO Abbreviation:  Cell Transplant     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nutritional and host effects on methanogenesis in the grazing ruminant.
Next Document:  Cathepsins and pancreatic cancer: The 2012 update.