|Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children.|
|PMID: 19922034 Owner: NLM Status: MEDLINE|
|OBJECTIVE: To determine whether an exercise intervention using an active video game (Dance Dance Revolution [DDR]) is effective in improving endothelial dysfunction (EDF) and other risk factors in overweight children. DESIGN: Thirty-five children (Body mass index > or = 85(th) percentile, mean age 10.21+/-1.67 years, 17 females) with EDF were assessed for flow-mediated dilation (FMD), lipids, insulin, glucose, NO(2)+NO(3), asymmetric dimethylarginine, symmetric dimethylarginine, l-arginine, height, weight, aerobic fitness, and blood pressure. In a subsample, tumor necrosis factor alpha, interleukin-6, C-reactive protein, and adiponectin were also assessed. Subjects were randomly assigned to 12-weeks of aerobic exercise (EX) using DDR or to a non-exercising delayed-treatment control group (DTC). RESULTS: EX had significant improvements in FMD ( 5.56+/-5.04% compared with 0.263+/-4.54%, p=0.008), exercise time on the graded exercise test (53.59+/-91.54 compared with -12.83+/-68.10 seconds, p=0.025), mean arterial pressure (MAP) (-5.62+/-7.03 compared with -1.44+/-2.16 mmHg, p=0.05), weight (0.91+/-1.53 compared with 2.43+/-1.80 kg, p=0.017) and peak VO(2) (2.38+/-3.91 compared with -1.23+/-3.18 mg/kg/min, p=0.005) compared with the DTC. Thirteen EX subjects achieved normal EDF while ten did not. These groups differed at baseline with regard to total cholesterol (TC) and low-density lipoprotein (LDL). CONCLUSION: Twelve weeks of DDR-use improved FMD, aerobic fitness, and MAP in overweight children. Improvements occurred without changes in inflammatory markers or nitric oxide production. The results document the need to explore relationships between obesity, endothelial function, inflammation, lipids, exercise intensity, and gender in a larger sample of overweight children.|
|Emily C-S Murphy; Linda Carson; William Neal; Christine Baylis; David Donley; Rachel Yeater|
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|Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't|
|Title: International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity Volume: 4 ISSN: 1747-7174 ISO Abbreviation: Int J Pediatr Obes Publication Date: 2009|
|Created Date: 2009-11-20 Completed Date: 2010-01-28 Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 101256330 Medline TA: Int J Pediatr Obes Country: England|
|Languages: eng Pagination: 205-14 Citation Subset: IM|
|Department of Pediatrics, Robert C. Byrd, Health Science Center, West Virginia University, Morgantown, West Virginia 26506-9214, USA. email@example.com|
|APA/MLA Format Download EndNote Download BibTex|
analogs & derivatives,
Biological Markers / blood
Blood Glucose / metabolism
Body Mass Index
Brachial Artery / metabolism, physiopathology*, ultrasonography
Endothelium, Vascular / metabolism, physiopathology*
Inflammation Mediators / blood
Insulin / blood
Lipids / blood
Nitrates / blood
Nitrites / blood
Overweight / blood, etiology, physiopathology, therapy*
|R01 DK056843/DK/NIDDK NIH HHS|
|0/Biological Markers; 0/Blood Glucose; 0/Inflammation Mediators; 0/Lipids; 0/Nitrates; 0/Nitrites; 11061-68-0/Insulin; 30315-93-6/N,N-dimethylarginine; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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