Document Detail


Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children.
MedLine Citation:
PMID:  19922034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether an exercise intervention using an active video game (Dance Dance Revolution [DDR]) is effective in improving endothelial dysfunction (EDF) and other risk factors in overweight children. DESIGN: Thirty-five children (Body mass index > or = 85(th) percentile, mean age 10.21+/-1.67 years, 17 females) with EDF were assessed for flow-mediated dilation (FMD), lipids, insulin, glucose, NO(2)+NO(3), asymmetric dimethylarginine, symmetric dimethylarginine, l-arginine, height, weight, aerobic fitness, and blood pressure. In a subsample, tumor necrosis factor alpha, interleukin-6, C-reactive protein, and adiponectin were also assessed. Subjects were randomly assigned to 12-weeks of aerobic exercise (EX) using DDR or to a non-exercising delayed-treatment control group (DTC). RESULTS: EX had significant improvements in FMD ( 5.56+/-5.04% compared with 0.263+/-4.54%, p=0.008), exercise time on the graded exercise test (53.59+/-91.54 compared with -12.83+/-68.10 seconds, p=0.025), mean arterial pressure (MAP) (-5.62+/-7.03 compared with -1.44+/-2.16 mmHg, p=0.05), weight (0.91+/-1.53 compared with 2.43+/-1.80 kg, p=0.017) and peak VO(2) (2.38+/-3.91 compared with -1.23+/-3.18 mg/kg/min, p=0.005) compared with the DTC. Thirteen EX subjects achieved normal EDF while ten did not. These groups differed at baseline with regard to total cholesterol (TC) and low-density lipoprotein (LDL). CONCLUSION: Twelve weeks of DDR-use improved FMD, aerobic fitness, and MAP in overweight children. Improvements occurred without changes in inflammatory markers or nitric oxide production. The results document the need to explore relationships between obesity, endothelial function, inflammation, lipids, exercise intensity, and gender in a larger sample of overweight children.
Authors:
Emily C-S Murphy; Linda Carson; William Neal; Christine Baylis; David Donley; Rachel Yeater
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity     Volume:  4     ISSN:  1747-7174     ISO Abbreviation:  Int J Pediatr Obes     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256330     Medline TA:  Int J Pediatr Obes     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-14     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Robert C. Byrd, Health Science Center, West Virginia University, Morgantown, West Virginia 26506-9214, USA. emurphy@hsc.wvu.edu
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MeSH Terms
Descriptor/Qualifier:
Arginine / analogs & derivatives,  blood
Biological Markers / blood
Blood Glucose / metabolism
Blood Pressure
Body Height
Body Mass Index
Body Weight
Brachial Artery / metabolism,  physiopathology*,  ultrasonography
Child
Dance Therapy*
Endothelium, Vascular / metabolism,  physiopathology*
Exercise Therapy*
Female
Humans
Inflammation Mediators / blood
Insulin / blood
Lipids / blood
Male
Nitrates / blood
Nitrites / blood
Overweight / blood,  etiology,  physiopathology,  therapy*
Oxygen Consumption
Patient Compliance
Physical Fitness
Risk Factors
Time Factors
Treatment Outcome
Vasodilation*
Video Games*
Grant Support
ID/Acronym/Agency:
R01 DK056843/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Inflammation Mediators; 0/Lipids; 0/Nitrates; 0/Nitrites; 11061-68-0/Insulin; 30315-93-6/N,N-dimethylarginine; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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