| Effects of exercise intensity on insulin sensitivity in women with non-insulin-dependent diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 7713829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Exercise enhances insulin sensitivity in people with non-insulin-dependent diabetes mellitus (NIDDM), but the intensity of exercise necessary to optimize the effect is unknown. Eight women with NIDDM were studied on a metabolic ward in each of three conditions: 1) low-intensity exercise (LO) that consisted of treadmill walking at 50% of maximal O2 consumption on days 1 and 2, 2) high-intensity exercise (HI) that consisted of walking at 75% of maximal O2 consumption, and 3) no exercise (NX). The duration of exercise was adjusted so that energy expenditure was equal in both exercise conditions. On day 3, glucose, [6,6-2H]glucose, and insulin were infused at fixed rates for 3 h. Insulin sensitivity was determined both by steady-state plasma glucose concentration and rate of glucose disposal per unit plasma insulin. Steady-state plasma glucose concentration and rate of glucose disposal per unit plasma insulin were almost identical after LO or HI; values were significantly greater than after NX. Plasma glucose response to a test meal was the same among the three conditions, but plasma insulin response was lower for HI and LO compared with NX. We conclude that under these conditions LO is as effective as HI in enhancing insulin sensitivity in people with NIDDM. |
| | |
Authors:
|
B Braun; M B Zimmermann; N Kretchmer |
Related Documents
:
|
8641319 - Low-dose iloprost infusion improves insulin action and non-oxidative glucose metabolism... 2951129 - Reversal of insulin resistance in type 1 diabetes following initiation of insulin treat... 22361889 - Difference in glucose intolerance between c57bl/6j and icr strain mice with streptozoto... 22470009 - Impact of different protein sources in the glycemic and insulinemic responses. 22723579 - Diabetic ketoacidosis at diagnosis influences complete remission after treatment with h... 17192339 - Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. 1828239 - Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. in ... 9388499 - Hyperinsulinemia but no diabetes in transgenic mice homozygously expressing the tyrosin... 18449539 - Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 78 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1995 Jan |
Date Detail:
|
Created Date: 1995-05-18 Completed Date: 1995-05-18 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 300-6 Citation Subset: IM |
Affiliation:
|
Department of Nutritional Sciences, University of California, Berkeley 94720. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Glucose / metabolism Body Composition / physiology Body Weight / physiology C-Peptide / blood Diabetes Mellitus, Type 2 / physiopathology* Diet Exercise / physiology* Female Humans Insulin / blood, diagnostic use, physiology* Middle Aged Oxidation-Reduction |
| Grant Support | |
ID/Acronym/Agency:
|
5-T32-HD-07255-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanical load affects growth and maturation of skeletal muscle grafts.
Next Document: Beta-adrenoceptor blockade and skeletal muscle energy metabolism during endurance exercise.