| Effects of exercise-induced weight loss on low density lipoprotein subfractions in healthy men. | |
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MedLine Citation:
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PMID: 2783076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One-year changes in low density lipoprotein (LDL) peak flotation (Sf) rate and serum mass concentrations of LDL of Sf 0 to 7 (small LDL), LDL of Sf 7 to 12 (large LDL), intermediate density lipoprotein (IDL) of Sf 12 to 20, and very low density lipoprotein (VLDL) of Sf 20 to 400 were compared between men assigned at random to a 1-year exercise program (N = 48) or to a sedentary control condition (N = 31). Distance run among exercisers varied substantially (mean +/- SD: 12.7 +/- 8.9 km/week). Mean changes were not significantly different between the exercise and control groups for any of the low to very low density lipoprotein measurements. However, within the exercise group: 1) distance run correlated negatively with changes in the mass concentrations of small LDL; and 2) weight loss and reduced upper body obesity correlated positively with changes in small LDL, IDL, and VLDL mass and negatively with change in LDL peak flotation rate. Analyses with partial correlations suggest that weight loss may primarily affect LDL mass distributions through metabolic processes associated with high density lipoprotein2 or small VLDL (Sf 20 to 60). The decrease in small LDL concentrations and the increase in LDL peak flotation rate suggest that exercise-induced weight loss may be effective in reducing coronary heart disease risk in persons genetically predisposed to a high-risk lipoprotein profile. |
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Authors:
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P T Williams; R M Krauss; K M Vranizan; J J Albers; R B Terry; P D Wood |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 9 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1989 Sep-Oct |
Date Detail:
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Created Date: 1989-10-19 Completed Date: 1989-10-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 623-32 Citation Subset: IM |
Affiliation:
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Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, California 94305. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise* Humans Lipoproteins, LDL / blood*, classification Male Middle Aged Osmolar Concentration Reference Values Running Time Factors Weight Loss* |
| Grant Support | |
ID/Acronym/Agency:
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HL-02183/HL/NHLBI NIH HHS; HL-24462/HL/NHLBI NIH HHS; HL-33577/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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