Document Detail


Effects of exercise-induced arterial hypoxaemia and work rate on diaphragmatic fatigue in highly trained endurance athletes.
MedLine Citation:
PMID:  16439429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diaphragmatic fatigue occurs in highly trained athletes during exhaustive exercise. Since approximately half of them also exhibit exercise-induced arterial hypoxaemia (EIAH) during high-intensity exercise, the present study sought to test the hypothesis that arterial hypoxaemia contributes to exercise-induced diaphragmatic fatigue in this population. Ten cyclists ( : 70.0 +/- 1.6 ml kg(-1) min(-1); mean +/-s.e.m.) completed, in a balanced ordering sequence, one normoxic (end-exercise arterial O(2) saturation (S(a,O(2))): 92 +/- 1%) and one hyperoxic (F(I,O(2)): 0.5% O(2); S(a,O(2)) : 97 +/- 1%) 5 min exercise test at intensities equal to 80 +/- 3 and 90 +/- 3% of maximal work rate (WR(max)), respectively, producing the same tidal volume (V(T)) and breathing frequency (f) throughout exercise. Cervical magnetic stimulation was used to determine reduction in twitch transdiaphragmatic pressure (P(di,tw)) during recovery. Hyperoxic exercise at 90% WR(max) induced significantly (P= 0.022) greater post-exercise reduction in P(di,tw) (15 +/- 2%) than did normoxic exercise at 80% WR(max) (9 +/- 2%), despite the similar mean ventilation (123 +/- 8 and 119 +/- 8 l min(-1), respectively), breathing pattern (V(T): 2.53 +/- 0.05 and 2.61 +/- 0.05 l, f: 49 +/- 2 and 46 +/- 2 breaths min(-1), respectively), mean changes in P(di) during exercise (37.1 +/- 2.4 and 38.2 +/- 2.8 cmH(2)O, respectively) and end-exercise arterial lactate (12.1 +/- 1.4 and 10.8 +/- 1.1 mmol l(-1), respectively). The difference found in diaphragmatic fatigue between the hyperoxic (at higher leg work rate) and the normoxic (at lower leg work rate) tests suggests that neither EIAH nor lactic acidosis per se are likely predominant causative factors in diaphragmatic fatigue in this population, at least at the level of S(a,O(2)) tested. Rather, this result leads us to hypothesize that blood flow competition with the legs is an important contributor to diaphragmatic fatigue in heavy exercise, assuming that higher leg work required greater leg blood flow.
Authors:
Ioannis Vogiatzis; Olga Georgiadou; Ifigenia Giannopoulou; Maria Koskolou; Spyros Zakynthinos; Konstantinos Kostikas; Epaminondas Kosmas; Harrieth Wagner; Eleni Peraki; Antonia Koutsoukou; Nickolaos Koulouris; Peter D Wagner; Charis Roussos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-26
Journal Detail:
Title:  The Journal of physiology     Volume:  572     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-14     Completed Date:  2006-06-20     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  539-49     Citation Subset:  IM    
Affiliation:
Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, M. Simou and GP Livanos Laboratories, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / etiology,  physiopathology*
Blood Gas Analysis
Diaphragm / physiopathology*
Exercise / physiology*
Humans
Lactates / blood
Leg / blood supply,  physiology
Male
Muscle Fatigue / physiology*
Oxygen / blood
Physical Endurance / physiology*
Physical Exertion / physiology*
Physical Fitness
Pulmonary Ventilation / physiology
Regional Blood Flow / physiology
Respiration
Tidal Volume
Time Factors
Chemical
Reg. No./Substance:
0/Lactates; 7782-44-7/Oxygen
Comments/Corrections

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