Document Detail

Effects of exercise-induced alterations of cardiac physiology on nuclear perfusion imaging.
MedLine Citation:
PMID:  7865548     Owner:  NLM     Status:  MEDLINE    
The effects produced on nuclear perfusion images by exercise-induced changes in the heart and respiration rate and possible transient myocardial stunning are not well understood. In this study we attempted to indirectly evaluate the potential artifacts created by exercise-induced changes in cardiac physiology. Twenty patients with prior myocardial infarction and suspected peri-infarct ischemia were studied by 99mTc-MIBI imaging. Two SPECT perfusion studies were performed after 99mTc-MIBI administration at rest. The first acquisition was carried out 90 minutes after injection of the tracer. Immediately afterwards, the patients underwent a stress test followed by a second acquisition (exercise stress superimposed on rest tracer distribution). A standard stress perfusion scan was also performed 48 hours later. Superimposed exercise stress produced artifactual defects in the resting distribution of the tracer in 15 out of 20 patients (68 of 360 segments). Standard stress images demonstrated concordant defects in 48 of these segments, indicating the concomitant presence of ischemia and stunning. This study indicates that exercise-induced changes in cardiac physiology may result in artifactual perfusion defects in scintigraphic images acquired shortly after the stress.
P L Zanco; R Buchberger; N Borsato; B Saitta; F Chierichetti; G L Suzi; C Orlandi; G Ferlin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear biology and medicine (Turin, Italy : 1991)     Volume:  38     ISSN:  0368-3249     ISO Abbreviation:  J Nucl Biol Med     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110209     Medline TA:  J Nucl Biol Med     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  508-13     Citation Subset:  IM    
Division of Nuclear Medicine, San Giacomo Hospital, Veneto, Italy.
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MeSH Terms
Contrast Media* / pharmacology
Exercise Test*
Heart / physiopathology*,  radionuclide imaging
Middle Aged
Myocardial Stunning / physiopathology,  radionuclide imaging*
Respiration / physiology
Technetium Tc 99m Sestamibi / diagnostic use*,  pharmacology
Reg. No./Substance:
0/Contrast Media; 109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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