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Effects of exercise in experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis).
MedLine Citation:
PMID:  24999244     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Exercise training has improved many outcomes in "clinical" research involving persons with multiple sclerosis (MS), but there is limited understanding of the underlying "basic" pathophysiological mechanisms. The animal model of MS, experimental autoimmune encephalomyelitis (EAE), seems ideal for examining the effects of exercise training on MS-disease pathophysiology. EAE is an autoimmune T-helper cell-mediated disease characterized by T-cell and monocyte infiltration and inflammation in the CNS. To that end, this paper briefly describes common models of EAE, reviews existing research on exercise and EAE, and then identifies future research directions for understanding the consequences of exercise training using EAE.
Authors:
Rachel E Klaren; Robert W Motl; Jeffrey A Woods; Stephen D Miller
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Publication Detail:
Type:  REVIEW     Date:  2014-6-24
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-7-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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