Document Detail


Effects of exercise and grape juice ingestion in combination on plasma concentrations of purine bases and uridine.
MedLine Citation:
PMID:  18035056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Since grape juice contains considerable amounts of fructose, which may increase the plasma concentration of urate, the combination of exercise and grape juice may increase the plasma concentration of urate to a greater degree than grape juice or exercise alone. METHODS: We performed 3 experiments with 6 healthy male Japanese. The first was exercise alone (exercise alone experiment), the second was grape juice ingestion alone (grape juice alone experiment), and the third was a combination of exercise and grape juice ingestion (combination experiment). RESULTS: In the exercise alone experiment, the concentrations of purine bases and uridine in plasma, and lactate in blood, as well as the urinary excretion of oxypurines were increased, whereas the urinary excretion of uric acid and fractional excretion of purine bases were decreased. In the grape juice alone experiment, the concentrations of purine bases and uridine, as well as lactate in blood were increased, whereas the fractional excretion of uric acid was decreased. In the combination experiment, the concentrations of purine bases and uridine in plasma, and lactate in blood, as well as the urinary excretion of oxypurines were increased, whereas the urinary excretion of uric acid and fractional excretion of hypoxanthine, xanthine, and uric acid were decreased. The increase in plasma concentration of urate by the combination of exercise and grape juice was greater than that by each alone, though it was not significantly different from the sum of increases in those 2 experiments. CONCLUSION: Increases in adenine nucleotide degradation and lactic acid production caused by both exercise and grape juice ingestion play an important role in the increase in plasma concentration of urate, while those in combination have an additive effect on that concentration.
Authors:
Masao Ohno; Tuneyoshi Ka; Taku Inokuchi; Yuji Moriwaki; Asako Yamamoto; Sumio Takahashi; Zenta Tsutsumi; Junzou Tsuzita; Tetsuya Yamamoto; Shuhei Nishiguchi
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Publication Detail:
Type:  Journal Article     Date:  2007-11-05
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  388     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Beverages*
Creatine / blood
Eating*
Exercise / physiology*
Humans
Insulin / blood
Male
Purines / blood*
Uric Acid / blood
Uridine / blood*
Vitis*
Chemical
Reg. No./Substance:
0/Purines; 11061-68-0/Insulin; 120-73-0/purine; 57-00-1/Creatine; 58-96-8/Uridine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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