Document Detail


Effects of exercise combined with caloric restriction on inflammatory cytokines.
MedLine Citation:
PMID:  20962912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic inflammation has been implicated in the pathogenesis of several chronic diseases, such as atherosclerosis and diabetes, as well as certain types of cancers. It has been suggested that circulating biomarkers for inflammation may be modified by exercise; however, few laboratory-based studies have been conducted in nonobese premenopausal women. The purpose of this investigation was to determine the impact of a 4-month exercise training and caloric-restriction intervention with the goal of weight loss on circulating biomarkers of inflammation in sedentary premenopausal women aged 25- 40 years (weight, 57 ± 2 kg). Subjects were studied for 6 consecutive menstrual cycles: 1 Screening, 1 Baseline, then 4 interventions (Interventions 1-4). Supervised aerobic training, consisting primarily of treadmill running and elliptical machine exercise, was performed 4 times per week for 40-90 min at 79% ± 0.7% of maximal heart rate. Subjects also consumed 30% fewer calories vs. baseline (1863 ± 58 to 1428 ± 53 kcalday(-1) (1 kcal = 4.186 kJ), p < 0.0001). Circulating inflammatory biomarkers, including adiponectin, high-sensitivity (hs) C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interferon-gamma (IFN-γ), and leptin, as well as body composition, aerobic capacity, and energy balance, were measured before and after the intervention. Maximal aerobic capacity increased by 8.5 ± 1.7 mL kg(-1)min-1 (p < 0.001) and body mass declined by an average of 3.7 ± 0.5 kg (p < 0.001). Significant reductions in IL-6 (0.39 ± 0.04 to 0.30 ± 0.03 pgmL(-1), p = 0.025), IFN-γ (0.58 ± 0.83 to 0.42 ± 0.64 pgmL-1, p = 0.030), and leptin (13.18 ± 1.28 to 6.28 ± 0.71 pgmL(-1), p < 0.001) were detected in response to the intervention. No significant changes in adiponectin, hs-CRP, or TNF-α were found. Weight loss in response to exercise training and caloric restriction is effective in reducing inflammatory markers, specifically IL-6 and leptin.
Authors:
Jennifer L Reed; Mary Jane De Souza; Nancy I Williams
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  35     ISSN:  1715-5312     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-12-10     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  573-82     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, Women's Health and Exercise Laboratory, Noll Laboratories, Penn State University, University Park, PA 16802, USA.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adult
Biological Markers / blood*
Body Composition / immunology
C-Reactive Protein / metabolism
Caloric Restriction / methods*
Energy Metabolism / immunology
Exercise / physiology*
Female
Humans
Inflammation / blood,  metabolism,  physiopathology*
Interferon-gamma / blood
Interleukin-6 / blood
Leptin / blood
Patient Dropouts
Physical Fitness / physiology
Premenopause / physiology*
Tumor Necrosis Factor-alpha / blood
Grant Support
ID/Acronym/Agency:
M01RR10732/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/IL6 protein, human; 0/Interleukin-6; 0/Leptin; 0/Tumor Necrosis Factor-alpha; 82115-62-6/Interferon-gamma; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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