Document Detail

Effects of exercise on cardiovascular outcomes in monkeys with risk factors for coronary heart disease.
MedLine Citation:
PMID:  12649090     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Exercise reduces the risk for coronary heart disease. However, the mechanisms mediating the beneficial effects of exercise remain ambiguous. In particular, it is uncertain whether exercise inhibits the development of atherosclerosis, a major pathobiologic process underlying heart disease. METHODS AND RESULTS: To address this question, adult male monkeys were fed an atherogenic diet while assigned to one of four experimental conditions for 34 months: 1) runner/no group disruption, ie, "stable" (n=19); 2) runner plus frequent social group disruption, ie, "unstable" (n=19); 3) sedentary/stable (n=15); or 4) sedentary/unstable (n=18). Neither exposure to exercise nor social group disruption significantly affected the resulting coronary artery atherosclerosis extent or lumen areas (all ANOVA values, P>0.05). When compared with sedentary individuals, exercise animals had lower resting heart rates (119.0+/-3 vs 132.0+/-3 bpm, P=0.002), greater echocardiographically measured left ventricular ejection fractions (77.2+/-0.01% vs 73.8+/-0.01%, P=0.02), greater quantitative angiographically measured dilation of coronary arteries to phenylephrine (2.6+/-1% vs -3.7+/-1% change from baseline diameter, P=0.003), and a reduced cortisol response to an adrenocorticotropin challenge. These measures were not significantly affected by social condition. CONCLUSIONS: Thus, exercise improved some measures of cardiovascular health and reduced stress responsivity but did not inhibit progression of coronary artery atherosclerosis or promote positive artery remodeling. It is concluded that exercise may exert cardioprotective effects without influencing atherosclerosis extent.
J Koudy Williams; Jay R Kaplan; Irma H Suparto; Jamie L Fox; Stephen B Manuck
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-03-20
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  23     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-12     Completed Date:  2004-03-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  864-71     Citation Subset:  IM    
Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157, USA.
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MeSH Terms
Adrenocorticotropic Hormone / diagnostic use
Blood Pressure
Coronary Artery Disease / etiology,  pathology,  prevention & control*,  ultrasonography
Coronary Vessels / drug effects,  ultrastructure
Diet, Atherogenic
Disease Progression
Heart Rate
Hydrocortisone / secretion
Lipids / blood
Macaca fascicularis
Phenylephrine / pharmacology
Physical Conditioning, Animal*
Risk Factors
Social Behavior
Stroke Volume
Treatment Outcome
Vasodilator Agents / pharmacology
Grant Support
Reg. No./Substance:
0/Lipids; 0/Vasodilator Agents; 50-23-7/Hydrocortisone; 59-42-7/Phenylephrine; 9002-60-2/Adrenocorticotropic Hormone

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