Document Detail


Effects of exercise on the capillary vasculature of the rat heart.
MedLine Citation:
PMID:  2947746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects on the myocardium, particularly those structural properties of the capillary network relevant to tissue oxygenation, were studied morphometrically in rats subjected to moderate exercise, strenuous exercise, and strenuous exercise preceded by a preconditioning period of moderate exercise. These different modalities of exercise were used to test the hypothesis that endurance training leads to capillary proliferation in the heart. The findings indicate that treadmill running produces right ventricular hypertrophy exclusively, which is accompanied by lengthening of the myocytes. Furthermore, a moderate running program results in an increase in the numerical density, luminal surface, and total length of capillaries in the right ventricle. In contrast, strenuous exercise with or without a preconditioning period produces a relative decrease in capillary luminal volume, surface, and numerical density. In the former case the diffusion distance for oxygen is decreased and in the latter it is increased. These data suggest that moderate exercise affects the microvasculature in ways that improve the efficiency of tissue oxygenation in the myocardium, whereas strenuous exercise has the opposite effect.
Authors:
P Anversa; R Ricci; G Olivetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  75     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I12-8     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Capillaries
Cardiomegaly / pathology
Coronary Circulation*
Heart / anatomy & histology
Male
Myocardium / pathology
Physical Exertion*
Rats
Grant Support
ID/Acronym/Agency:
HL-24479/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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