Document Detail

Effects of exercise on aortic input impedance and pressure wave forms in normal humans.
MedLine Citation:
PMID:  7460206     Owner:  NLM     Status:  MEDLINE    
The effects of supine bicycle exercise on the input impedance of the ascending aorta were studied in thirteen male subjects undergoing cardiac catheterization, but in whom no cardiovascular disease was found. Ascending aortic flow velocity and pressure were recorded simultaneously from a multisensor catheter with an electromagnetic flow velocity probe and a pressure sensor mounted at the same location. A second pressure sensor at the catheter tip provided left ventricular pressure. Fick cardiac outputs were used to scale the velocity signal to instantaneous volumetric flow. Input impedance was calculated from 10 harmonics of aortic pressure and flow. For each subject, impedance moduli and phases from a minimum of 15 beats during rest and exercise were averaged. Peripheral resistance decreased from a resting value of 1142 +/- 51 (+/- SE) dynes sec/cm5 to 712 +/- 39 dynes sec/cm5 during exercise. Characteristic impedance remained unchanged with a resting value of 47 +/- 4 dynes sec/cm5 and an exercise value of 45 +/- 4 dynes sec/cm5. These results were associated with an increase in aortic pressure (96 +/- 2 to 111 +/- 2 mm Hg) and pulse wave velocity implying a decrease in aortic compliance. An increase in aortic cross-sectional area apparently offsets the effects of these changes in compliance and pulse wave velocity to result in an unchanged characteristic impedance. The increase in pulse wave velocity caused wave reflections to occur earlier during exercise, but the general characteristics of the pressure wave shapes remained unchanged.
J P Murgo; N Westerhof; J P Giolma; S A Altobelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation research     Volume:  48     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-43     Citation Subset:  IM; S    
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MeSH Terms
Aorta / physiology*
Blood Pressure*
Cardiac Output
Heart Rate
Physical Exertion*
Stroke Volume
Vascular Resistance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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