Document Detail

Effects of exercise on adiponectin: a systematic review.
MedLine Citation:
PMID:  18239630     Owner:  NLM     Status:  MEDLINE    
Secreted from white adipose tissue, circulating concentrations of adiponectin are reduced in the presence of metabolic and cardiovascular disease such as obesity and type 2 diabetes. The aim of this systematic review is to assess the body of evidence critically for the effects of exercise on adiponectin levels. Literature searches using the Medline, CINAHL, Cochrane Controlled Trials registry, EMBASE, and SportDiscus databases were conducted from 1966 to September 2006 using keywords pertaining to "adiponectin" and "exercise." Thirty-three trials met the inclusion criteria. Study designs consisted of 5 cross-sectional studies, 7 trials of acute exercise, 11 uncontrolled trials, 2 non-randomized controlled trials, and 8 randomized controlled trials (RCTs). Exercise of varying prescription has been shown to increase serum adiponectin in 38% of RCTs, demonstrating small-to-moderate effect sizes (ESs). One study reported a dose-response effect of resistance training intensity and the augmentation of adiponectin. Inconsistent support in the literature exists for increasing adiponectin levels after short-term exposure to robust aerobic or resistance training of moderate-to-high intensities. Particular attention should be directed toward high-risk cohorts, in whom augmentation of the anti-inflammatory cytokine adiponectin may assume critical importance.
Kylie A Simpson; Maria A Fiatarone Singh
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  16     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-56     Citation Subset:  IM    
School of Exercise and Sport Science, University of Sydney, Sydney, NSW, Australia.
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MeSH Terms
Adiponectin / blood*
Controlled Clinical Trials as Topic
Cross-Sectional Studies
Exercise / physiology*
Health Status
Middle Aged
Outcome Assessment (Health Care)
Randomized Controlled Trials as Topic
Reg. No./Substance:

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