Document Detail

Effects of excitotoxic amino acids on pituitary hormone secretion in the rat.
MedLine Citation:
PMID:  6318903     Owner:  NLM     Status:  MEDLINE    
The acute effects of administration of 4 excitatory amino acids (n-methyl-DL-aspartic acid (NMA), kainic acid (KA), ibotenic acid (IA) and quinolinic acid (QA] on the serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH) and prolactin (PRL) were studied in the rat. NMA-treated rats exhibited increased serum LH and GH concentrations while KA-treated rats-showed increases only in serum GH concentrations. Neither IA nor QA altered adenohypophyseal hormone levels. These endocrine alterations induced by NMA and KA are different from those previously reported after administration of glutamate, another excitatory amino acid. The finding that all of the excitatory amino acids studied did not produce identical effects on anterior pituitary hormone secretion may be due to differential permeability of these substances into the central nervous system or because they act at different subtypes of excitatory amino acid receptors.
G A Mason; G Bissette; C B Nemeroff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  289     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-12     Completed Date:  1984-03-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  366-9     Citation Subset:  IM    
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MeSH Terms
Amino Acids / pharmacology*
Follicle Stimulating Hormone / blood
Growth Hormone / blood
Luteinizing Hormone / blood
Pituitary Gland, Anterior / drug effects*
Pituitary Hormones, Anterior / blood*
Prolactin / blood
Rats, Inbred Strains
Synaptic Transmission / drug effects*
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Pituitary Hormones, Anterior; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-72-6/Growth Hormone

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