| Effects of excitotoxic amino acids on pituitary hormone secretion in the rat. | |
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MedLine Citation:
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PMID: 6318903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute effects of administration of 4 excitatory amino acids (n-methyl-DL-aspartic acid (NMA), kainic acid (KA), ibotenic acid (IA) and quinolinic acid (QA] on the serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH) and prolactin (PRL) were studied in the rat. NMA-treated rats exhibited increased serum LH and GH concentrations while KA-treated rats-showed increases only in serum GH concentrations. Neither IA nor QA altered adenohypophyseal hormone levels. These endocrine alterations induced by NMA and KA are different from those previously reported after administration of glutamate, another excitatory amino acid. The finding that all of the excitatory amino acids studied did not produce identical effects on anterior pituitary hormone secretion may be due to differential permeability of these substances into the central nervous system or because they act at different subtypes of excitatory amino acid receptors. |
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Authors:
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G A Mason; G Bissette; C B Nemeroff |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 289 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-03-12 Completed Date: 1984-03-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 366-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacology* Animals Follicle Stimulating Hormone / blood Growth Hormone / blood Luteinizing Hormone / blood Male Pituitary Gland, Anterior / drug effects* Pituitary Hormones, Anterior / blood* Prolactin / blood Rats Rats, Inbred Strains Synaptic Transmission / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HD-03110/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Pituitary Hormones, Anterior; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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