Document Detail

Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
MedLine Citation:
PMID:  14745162     Owner:  NLM     Status:  MEDLINE    
We investigated a useful chemical index for an excessive nicotinamide intake and how this excessive nicotinamide intake affects the tryptophan-nicotinamide metabolism in rats. Weaning rats were fed on a tryptophan-limited and nicotinic acid-free diet containing no, 0.003%, 0.1%, 0.2%, or 0.3% nicotinamide for 21 days. Urine samples were collected on the last day and analyzed the intermediates and metabolites on the tryptophan-nicotinamide pathway. Nicotinamide N-oxide, nicotinic acid and nicotinuric acid, metabolites of nicotinamide, were detected when nicotinamide at more than 0.1% had been taken. An intake of nicotinamide of more than 0.1% increased the urinary excretion of quinolinic acid, an intermediate on the pathway. Nicotinamide N-oxide and nicotinuric acid increased with increasing dietary concentration of nicotinamide. These results show that the measurements of nicotinamide N-oxide and nicotinuric acid in urine would be useful indices for an excessive nicotinamide intake.
Tsutomu Fukuwatari; Hideko Wada; Ryuzo Sasaki; Katsumi Shibata
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  68     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.
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MeSH Terms
Dose-Response Relationship, Drug
Eating / drug effects
Liver / drug effects,  metabolism
NAD / blood,  metabolism
NADP / blood,  metabolism
Niacinamide / administration & dosage*,  analogs & derivatives*,  metabolism,  pharmacokinetics,  urine*
Nicotinic Acids / urine*
Predictive Value of Tests
Quinolinic Acid / urine
Rats, Wistar
Tryptophan / metabolism
Weight Gain / drug effects
Reg. No./Substance:
0/Nicotinic Acids; 1986-81-8/nicotinamide N-oxide; 53-59-8/NADP; 53-84-9/NAD; 583-08-4/nicotinuric acid; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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