Document Detail


Effects of ethanol on the ultrastructure of the hamster femur.
MedLine Citation:
PMID:  11510966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several previous studies have indicated that chronic ingestion of ethanol exerts harmful effects on bones. However, few data are available concerning the effects of ethanol on the ultrastructure of bone. To further elucidate the effects of ethanol on bone, we studied the morphology of femur in golden hamsters after long-term treatment with ethanol. Six-week-old male hamsters were divided into 4 groups. Ethanol-treated animals were given ethanol at a concentration of 7% with food and water freely available, whereas the pair-fed animals (weight-matched to ethanol hamsters) had tap water available as the only drinking fluid. The femur weight, blood ethanol and serum calcium concentrations were determined after 3 and 5 months. The bone mineral density (BMD) of the whole body was measured before and after the experiment. Femurs of both sides were dissected and processed for morphometric measurement, light microscopy, scanning and transmission electron microscopy. In the ethanol-treated hamsters, BMD of the whole body and the weight of femur tended to decrease when compared with those of the controls. Light microscopy and scanning electron microscopy showed that the trabecula in the distal end of the femur from ethanol-treated hamsters were thinner than those of the controls. We also observed the disrupted swollen mitochondria of the femoral osteoblasts and osteocytes in the ethanol-treated hamsters. No significant difference in serum calcium levels and femoral osteoclasts was found. These results indicate that long-term treatment with ethanol results in disruption of femoral osteoblasts and reduction of bone mass in trabecular bone.
Authors:
H Chen; D Hayakawa; S Emura; Y Ozawa; H Taguchi; R Yano; S Shoumura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  16     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-20     Completed Date:  2002-02-08     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  763-70     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Gifu University School of Medicine, Japan. huayue@cc.gifu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / blood,  pathology*
Animals
Bone Density / drug effects
Bone and Bones / drug effects,  ultrastructure
Calcium / blood
Cricetinae
Ethanol / blood,  toxicity*
Femur / drug effects*,  ultrastructure*
Male
Mesocricetus
Microscopy, Electron
Microscopy, Electron, Scanning
Mitochondrial Swelling / drug effects
Osteoblasts / drug effects,  ultrastructure
Osteoclasts / drug effects,  ultrastructure
Osteocytes / drug effects,  ultrastructure
Chemical
Reg. No./Substance:
64-17-5/Ethanol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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