| Effects of ethanol and methanol on lipid metabolism in Bacillus subtilis. | |
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MedLine Citation:
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PMID: 6788897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Bacillus subtilis, the fatty acid moiety of the phospholipids was affected differently during growth in the presence of 1.1 M-methanol or 0.7 M-ethanol, though at these concentrations methanol and ethanol had the same effects on growth rate and completely inhibited sporulation. Synthesis of phosphatidylglycerol was also strongly inhibited and the amount of total cell phospholipids was reduced by 50% by both alcohols. The composition of fatty acids, especially the relative concentration of 12-methyltetradecanoic acid, was modified only by ethanol; in bacteria grown in the presence of methanol, changes in fatty acid composition were negligible. In non-sporulating mutants, synthesis of phosphatidylglycerol was much less affected than in the wild-type and synthesis of phosphatidylethanolamine was increased. In these strains, fatty acid composition was also modified by ethanol but unaffected by methanol. |
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Authors:
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D Rigomier; J P Bohin; B Lubochinsky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of general microbiology Volume: 121 ISSN: 0022-1287 ISO Abbreviation: J. Gen. Microbiol. Publication Date: 1980 Nov |
Date Detail:
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Created Date: 1981-09-25 Completed Date: 1981-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375371 Medline TA: J Gen Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 139-49 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus subtilis
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drug effects,
growth & development,
metabolism* Ethanol / pharmacology* Fatty Acids / metabolism Lipid Metabolism* Methanol / pharmacology* Phosphatidylglycerols / metabolism Phospholipids / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Phosphatidylglycerols; 0/Phospholipids; 64-17-5/Ethanol; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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