| Effects of ethanol feeding and malnutrition on collagen synthesizing and degrading enzymes in rat pancreas. | |
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MedLine Citation:
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PMID: 8734836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was performed to delineate the combined effects of a low-fat diet and chronic ethanol ingestion on collagen metabolism in rat pancreas. Rats fed a very low-fat diet (5% of total calories as lipid) for 12 weeks developed malnutrition as judged by weight loss (-33% of the initial body weight) and low serum albumin and amylase levels. The pancreas of malnourished rats showed increased collagenase activity with respect to animals fed a 35% lipid diet (p < 0.05). Hydroxyproline content was higher in the pancreas of malnourished rats and collagenase activity correlated well with hydroxyproline content (r = 0.57, p = 0.0013). Ethanol feeding for 12 weeks, regardless of the nutritional state of the rats, did not change the synthesis and degradation rates of collagen in the pancreas. The present study suggests that malnutrition may have profound effects on collagen metabolism. |
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Authors:
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J M López; S Imperial; R Valderrama; A Giménez; A Parés; J Caballería; S Navarro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 13 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 1996 May-Jun |
Date Detail:
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Created Date: 1996-10-04 Completed Date: 1996-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-31 Citation Subset: IM |
Affiliation:
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Gastroenterology Service, Hospital Clínic i Provincial, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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blood Animals Collagen / biosynthesis, metabolism* Collagenases / metabolism Dietary Fats / administration & dosage Ethanol / administration & dosage, pharmacology* Hydroxyproline / metabolism Male Nutrition Disorders / enzymology* Pancreas / enzymology* Procollagen-Proline Dioxygenase / metabolism Rats Rats, Sprague-Dawley Serum Albumin / metabolism Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Serum Albumin; 51-35-4/Hydroxyproline; 64-17-5/Ethanol; 9007-34-5/Collagen; EC 1.14.11.2/Procollagen-Proline Dioxygenase; EC 3.2.1.-/Amylases; EC 3.4.24.-/Collagenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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