| Effects of ethanol consumption on periodontal inflammation in rats. | |
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MedLine Citation:
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PMID: 18434576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies suggest a correlation between ethanol consumption and periodontal disease. We hypothesized that elevated levels of blood reactive oxygen species following ethanol consumption may increase inflammation in periodontal tissue. Rats were divided into 4 groups (6-7 rats/group). Two groups were fed an ethanol-containing liquid diet, and 2 groups were fed a pair-fed control diet. In one of each dietary group, periodontitis was ligature-induced, while the other group was left unligated. Chronic ethanol feeding alone decreased the ratio of reduced/oxidized glutathione and increased 8-hydroxydeoxy-guanosine and tumor necrosis factor (TNF)-alpha levels in the gingiva. Blood hydroperoxides were also increased. In ligature-induced periodontitis lesions, ethanol feeding enhanced polymorpho-nuclear leukocyte infiltration and TNF-alpha expression. The results suggest that chronic alcohol consumption increased periodontal inflammation, oxidative damage, and TNF-alpha production and had an additive effect on polymorphonuclear leukocyte infiltration and gingival oxidative damage, increasing the severity of periodontal inflammation in the ligature model. |
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Authors:
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K Irie; T Tomofuji; N Tamaki; T Sanbe; D Ekuni; T Azuma; T Maruyama; T Yamamoto |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 87 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-24 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 456-60 Citation Subset: D; IM |
Affiliation:
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Department of Oral Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Okayama 700-8525, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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adverse effects*,
immunology,
pathology Animals Deoxyguanosine / analogs & derivatives, metabolism Disease Models, Animal Ethanol / pharmacology* Gingiva / drug effects*, immunology, metabolism, pathology Glutathione / metabolism Hydrogen Peroxide / blood Male Neutrophil Infiltration / drug effects Periodontitis / immunology, metabolism*, pathology Rats Rats, Wistar Reactive Oxygen Species / metabolism Severity of Illness Index Statistics, Nonparametric Tooth Cervix / drug effects, metabolism, pathology Tumor Necrosis Factor-alpha / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/8-hydroxy-2'-deoxyguanosine; 0/Reactive Oxygen Species; 0/Tumor Necrosis Factor-alpha; 64-17-5/Ethanol; 70-18-8/Glutathione; 7722-84-1/Hydrogen Peroxide; 961-07-9/Deoxyguanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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