| Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet. | |
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MedLine Citation:
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PMID: 22288377 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Expression of cytochrome P4502E1 (CYP2E1) is very much influenced by nutritional factors, especially carbohydrate consumption, and various results concerning the expression of CYP2E1 were obtained with a low-carbohydrate diet. This study describes the effects of ethanol treatment on CYP2E1 levels and its relationship with oxidative stress using a balanced standard diet to avoid low or high carbohydrate consumption. Rats were fed for 1, 2, 3, or 4 weeks a commercial diet plus an ethanol-sucrose solution. The results have shown that ethanol administration was associated with CYP2E1 induction and stabilization without related oxidative stress. Our findings suggest that experimental models with a low-carbohydrate/high-fat diet produce some undesirable CYP2E1 changes that are not present when a balanced standard diet is given. |
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Authors:
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Ligia A Azzalis; Fernando L A Fonseca; Karin A Simon; Fernanda Schindler; Leandro Giavarotti; Hugo P Monteiro; Luis A Videla; Virgínia B C Junqueira |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Drug and chemical toxicology Volume: - ISSN: 1525-6014 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801723 Medline TA: Drug Chem Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Universidade Federal de São Paulo , Diadema, São Paulo , Brasil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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