Document Detail

Effects of etanercept treatment on lipid profile in patients with moderate-to-severe chronic plaque psoriasis: a retrospective cohort study.
MedLine Citation:
PMID:  21983007     Owner:  NLM     Status:  Publisher    
Treatment with tumor necrosis factor alpha (TNF-α) inhibitors may have favourable effects on the lipid profile. This is the first study to assess the impact of etanercept on the lipid profile in patients with moderate-to-severe plaque psoriasis. To investigate the effect of etanercept on the lipid profile after 24 weeks of treatment in patients with moderate-to-severe plaque psoriasis. We conducted a retrospective cohort study reviewing the medical records of 45 consecutive patients who were treated for psoriasis with etanercept between June 2006 and September 2009. Demographic and clinical data were collected. Levels of total cholesterol, LDL-C, HDL-C, triglycerides, fasting glucose and C-reactive protein were recorded at the start of etanercept and at week 24. Levels of total cholesterol, LDL-C and triglycerides increased after 24 weeks of treatment with etanercept, with mean differences of 7.1 mg/dL (p=0.505), 2.0 mg/dL (p=0.718) and 2.8 mg/dL (p=0.180), respectively. HDL-C decreased, with a mean difference of -1.4 mg/dL (p=0.995). None of these changes were statistically significant. We found no favourable changes on the lipid profile after 24 weeks of treatment with etanercept in responding patients with chronic plaque psoriasis.
Sara Lestre; Filipa Diamantino; Luis Veloso; Ana Fidalgo; Ana Ferreira
Related Documents :
7020507 - Bronchoalveolar cells in advanced pulmonary sarcoidosis.
3843137 - Kveim test and mitochondrial antibodies in the differential diagnosis between primary b...
3847297 - Exudative pleural effusions secondary to gastrointestinal diseases.
18539477 - Is routine chest x-ray following mediastinal drain removal after cardiac surgery useful?
14339297 - Diazepam: a preliminary study of its effects on patients with athetoid cerebral palsy.
17826557 - Clinical manifestations of type iv ulna longitudinal dysplasia.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-10
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  -     ISSN:  1167-1122     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Dermatology Department, Hospital Santo António dos Capuchos, 1169-050 Lisbon, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Anticipatory postural adjustments in children with hemiplegia and diplegia.
Next Document:  Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women's ...