| Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female rats. | |
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MedLine Citation:
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PMID: 11294752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of estrogen on thermoregulatory vasomotion and heat-escape behavior were investigated in ovariectomized female rats supplemented with estrogen (replaced estrogen rats) or control saline (low estrogen rats). First, we measured tail temperature of freely moving rats at ambient temperatures (T(a)) between 13 and 31 degrees C. Tail temperature of the low estrogen rats was higher than that of the replaced estrogen rats at T(a) between 19 and 25 degrees C, indicating that the low estrogen rats exhibit more skin vasodilation than the replaced estrogen rats. There was no significant difference in oxygen consumption and core temperature between the two groups. Second, we analyzed heat-escape behaviors in a hot chamber where rats could obtain cold air by moving in and out of a reward area. The low estrogen rats kept T(a) at a lower level than did the replaced estrogen rats. These results imply that the lack of estrogen facilitates heat dissipation both by skin vasodilation and by heat-escape behavior. Ovariectomized rats may mimic climacteric hot flushes not only for autonomic skin vasomotor activity but also for thermoregulatory behavior. |
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Authors:
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T Hosono; X M Chen; A Miyatsuji; T Yoda; K Yoshida; M Yanase-Fujiwara; K Kanosue |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 280 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-04-11 Completed Date: 2001-05-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1341-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Yamadaoka 1 - 7, Suita, Osaka, 565-0871, Japan. hosono@sahs.med.osaka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects, physiology* Climacteric Drug Implants Escape Reaction / drug effects, physiology* Estradiol / administration & dosage, pharmacology* Estrogen Replacement Therapy Female Hot Temperature Models, Animal Motor Activity Ovariectomy Rats Rats, Wistar Reward Skin / blood supply* Skin Temperature / physiology* Tail Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Drug Implants; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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