| Effects of estrogen therapy on vaginal physiology during menopause. | |
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MedLine Citation:
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PMID: 2989746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vaginal physiology was evaluated in 23 postmenopausal women before estrogen replacement therapy and at 1, 3, 6, 12, 18, and 24 months while receiving conjugated equine estrogens (Premarin). Reversal of hormonal levels (17 beta-estradiol, gonadotropins) and vaginal cytology occurred within one month. Vaginal pH levels significantly decreased from a baseline mean of 5.2 to a level of 4.2 at 24 months (P less than .05). Women who were sexually active showed a greater decline in pH levels than did women who were sexually inactive. Maximum increases in amount of vaginal fluid and potassium levels were observed after three months of therapy. Vaginal blood flow and vaginal electropotential difference were significantly increased over baseline values at one month and again at 12 months (P less than .05) with a slow progressive improvement continuing throughout 24 months of estrogen replacement therapy. This study provides documented laboratory evidence to suggest that restoration of vaginal tissue function requires 18 to 24 months and explains why dyspareunia may persist in the early months of replacement therapy despite hormonal and cytologic return to premenopausal values. |
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Authors:
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J P Semmens; C C Tsai; E C Semmens; C B Loadholt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 66 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-07 Completed Date: 1985-08-07 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 15-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Aged Body Fluids / metabolism Estradiol / blood Estrogens, Conjugated (USP) / pharmacology, therapeutic use* Female Gonadotropins, Pituitary / blood Humans Hydrogen-Ion Concentration Menopause / drug effects* Middle Aged Potassium / metabolism Regional Blood Flow / drug effects Vagina / blood supply, metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens, Conjugated (USP); 0/Gonadotropins, Pituitary; 50-28-2/Estradiol; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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