Document Detail

Effects of estrogen on specific protein synthesis in the cockerel liver: an immunocytochemical study on major apoproteins in very low density and high density lipoproteins and albumin.
MedLine Citation:
PMID:  7379755     Owner:  NLM     Status:  MEDLINE    
The effects of estrogen on two major apolipoproteins, apoVLDL-II and apoA-I, and albumin synthesis have been studied morphologically in cockerels using immunocytochemical methods. After the administration of a single dose of diethylstilbesterol (5 mg), the number of apoVLDL-II-containing hepatocytes increased markedly. The reaction product was also detected in the sinusoids. In contrast, the number of apoA-1- and albumin-containing cells did not seem to change significantly after estrogen treatment. The number of albumin-containing hepatocytes was higher than the number of apoVLDL II- or apoA-I-containing cells in the basal state. After estrogen, apoVLDL-II-containing cells were much more abundant than the other two cell types. The morphological changes induced by estrogen are correlated well with changes in the concentration of the three proteins in plasma after estrogen treatment.
C T Lin; L Chan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  107     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-5     Citation Subset:  AIM; IM    
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MeSH Terms
Apoproteins / biosynthesis*
Diethylstilbestrol / pharmacology*
Lipoproteins, HDL / biosynthesis*
Lipoproteins, VLDL / biosynthesis*
Liver / drug effects,  metabolism*
Serum Albumin / biosynthesis*
Reg. No./Substance:
0/Apoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 0/Serum Albumin; 56-53-1/Diethylstilbestrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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