| Effects of estrogen and progestin on the CO2 sensitivity of hemispheric cerebral blood volume. | |
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MedLine Citation:
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PMID: 17975517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: High CO2 sensitivity is one of the major characteristics of the cerebrovascular bed. It has been shown to be influenced by many differrent factors (eg, sex hormones). DESIGN: The effect of ovariectomy and subsequent female sexual hormone treatment on the steady-state hemispheric cerebral blood volume and CO2 responsiveness of the hemispheric blood vessels was studied on anesthetized, ventilated, normotensive, normoxic rats. Cerebral blood volume was measured with Tomita's photoelectric method with Sandor's modification. RESULTS: Steady-state cerebral blood volume values in ovariectomized rats did not differ from those found in control animals. The CO2 responsiveness of hemispheric blood vessels was higher in ovariectomized and progestin-treated, but not estrogen-treated, animals compared with controls. CONCLUSIONS: Our results demonstrate that the CO2 sensitivity of the hemispheric vessels is sex hormone dependent. Estrogen and progestin treatment have opposite effects on this cerebral circulatory parameter. |
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Authors:
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Emese Szelke; Tamás Mersich; Bela Szekacs; Peter Sandor; Katalin Komjati; Szabolcs Varbiro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 15 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2008 Mar-Apr |
Date Detail:
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Created Date: 2008-03-11 Completed Date: 2008-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 346-51 Citation Subset: IM |
Affiliation:
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Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Blood Volume Carbon Dioxide / metabolism* Cerebrovascular Circulation / drug effects*, physiology Cerebrum / blood supply, drug effects*, metabolism Disease Models, Animal Estrogen Replacement Therapy* Estrogens / pharmacology* Female Ovariectomy Postmenopause Progestins / pharmacology* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Progestins; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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