Document Detail

Effects of estrogen on autotomy in normal and ovariectomized rats.
MedLine Citation:
PMID:  10450069     Owner:  NLM     Status:  MEDLINE    
Gonadal hormones may modulate analgesia responses induced by acute stress in humans and rats. To evaluate the effects of gonadal hormones in modifying neuropathic pain, we measured autotomy changes following sciatic nerve resection in ovariectomized rats and in the presence of estrogen replacement. Two groups of female rats were subjected to ovariectomy and sham surgery. Each group was then divided into two subgroups receiving subcutaneously sesame oil with or without estradiol benzoate (5 microg/day/rat). All rats then underwent sciatic nerve resection in one hindlimb. Degree of self-mutilation was measured daily for 8 weeks. Estradiol treatment resulted in significantly lower autotomy scores in ovariectomized rats (3.6 +/- 0.6 vs. 5.5 +/- 0.3, p < 0.01) and in sham-operated rats (3.4 +/- 0.7 vs. 5.1 +/- 0.4, p < 0.05). The results of this study indicate that estrogen can modify the autotomy behavior, an indicator of neuropathic pain, in rats after nerve injury.
C M Tsao; C M Ho; S K Tsai; T Y Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  59     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-13     Completed Date:  1999-10-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Departments of Anesthesiology, Veterans General Hospital-Taipei, and College of Medicine, National Yang-Ming University, Taipei, Taiwan/ROC.
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MeSH Terms
Chronic Disease
Estradiol / analogs & derivatives*,  pharmacology
Pain / psychology*
Pain Measurement / drug effects
Rats, Sprague-Dawley
Sciatic Nerve / physiology
Self Mutilation / psychology*
Time Factors
Reg. No./Substance:
50-28-2/Estradiol; 50-50-0/estradiol 3-benzoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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