| Effects of estradiol on very low density lipoprotein receptor mRNA levels in rabbit heart. | |
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MedLine Citation:
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PMID: 8034005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The VLDL receptor, a newly identified lipoprotein receptor, has a domain structure homologous with the LDL receptor but has one additional cysteine rich repeat in the ligand binding domain. To study the regulation of the VLDL receptor in vivo, we administered 17 alpha-ethinyl estradiol to rabbits and examined its effects on VLDL receptor mRNA levels in the heart, one of the organs with highly expressed VLDL receptors, by RNA blotting. The ventricular level of VLDL receptor mRNA increased dramatically after estradiol administration. We could not detect VLDL receptor mRNA in the liver even after estradiol administration. We have confirmed the enhanced expression of liver LDL receptor mRNA by estradiol, however, only weak expression of the LDL receptor was detected in the ventricle of the rabbit heart. These results suggest that estradiol exerts its effect on the VLDL receptor gene expression in the heart. |
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Authors:
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H Masuzaki; H Jingami; T Yamamoto; K Nakao |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 347 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-08-18 Completed Date: 1994-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Kyoto University Faculty of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA Probes Ethinyl Estradiol / pharmacology* Gene Expression / drug effects* Liver / metabolism Male Myocardium / metabolism* Nucleic Acid Hybridization RNA, Messenger / metabolism* Rabbits Receptors, LDL / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/RNA, Messenger; 0/Receptors, LDL; 0/VLDL receptor; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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