| Effects of estradiol alone and combined with norethisterone acetate on pulse-wave velocity in hypertensive postmenopausal women. | |
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MedLine Citation:
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PMID: 17135035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Arterial hypertension and postmenopausal reduction of estrogen levels may be involved in modifications of the stiffness of large arteries. OBJECTIVES: To evaluate the pulse-wave velocity (PWV) and indirectly the arterial stiffness in hypertensive postmenopausal women submitted to hormone therapy with estradiol alone or combined with norethisterone acetate. SUBJECTS: Forty-five hypertensive postmenopausal women were double-blindly, randomly assigned to three arms of treatment: placebo (group I); estradiol 2 mg/day (group II); or estradiol 2 mg/day and norethisterone acetate 1 mg/day (group III). METHODS: Arterial stiffness was assessed from PWV measurements of the common carotid and femoral arteries (CF-PWV) and the common carotid and radial arteries (CR-PWV) obtained using the automatic Complior(R) device, taken at baseline and after 12 weeks of treatment. RESULTS: After the 12-week treatment, values of CF-PWV and CR-PWV were not significantly different (p = 0.910 and p = 0.736, respectively) among the groups. Systolic blood pressure showed a positive correlation with CF-PWV in groups II and III (p = 0.02 and p < 0.001, respectively). CONCLUSIONS: PWV and arterial stiffness in postmenopausal hypertensive women did not reduce over a 12-week treatment with estradiol alone compared with the same period of treatment with estradiol combined with norethisterone acetate. |
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Authors:
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C G Arruda; J M Aldrighi; L A Bortolotto; I N Alecrin; J A F Ramires |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 22 ISSN: 0951-3590 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-11-30 Completed Date: 2007-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 557-63 Citation Subset: IM |
Affiliation:
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Women's Health Clinic, Public Health School and Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil. ccag@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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drug effects* Blood Pressure / drug effects Carotid Arteries / physiopathology Double-Blind Method Drug Combinations Estradiol / administration & dosage, pharmacology* Female Humans Hypertension / blood, physiopathology* Middle Aged Norethindrone / administration & dosage, analogs & derivatives*, pharmacology Placebos Postmenopause / blood, drug effects* Pulse* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Placebos; 38673-38-0/norethindrone acetate; 50-28-2/Estradiol; 68-22-4/Norethindrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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