Document Detail

Effects of esophageal varices obliteration by endoscopic variceal sclerotherapy on asialoscintigraphy and liver function test.
MedLine Citation:
PMID:  11804833     Owner:  NLM     Status:  Publisher    
Background: hepatic functional reserve is determined by the function and number of hepatocytes, as well as hepatic blood flow. In Japan, endoscopic injection sclerotherapy is often performed prophylactically in patients with high-risk esophageal varices. We examined the effects of blocking portosystemic shunts by this treatment on hepatic circulation and hepatocyte function as evaluated by 99mTc-GSA scintigraphy (HH15, LHL15), an examination via asialoglycoprotein receptors on hepatocytes. Methods: forty-nine patients who underwent prophylactic treatment of esophageal varices were divided into two groups; one having esophageal varices alone and the second having other collateral circulation in addition to esophageal varices. Asialoscintigraphy and general liver function tests were performed both before and after treatment in each group and the data were statistically analyzed. Results: In the group having esophageal varices alone, serum total bile acid significantly decreased at 62.2% and ICGR15, HH15, and LHL15 were slightly improved at -10.9, -3.0, and +4.7%, respectively, after sclerotherapy (P<0.01). However, Child-Pugh's score was not changed after sclerotherapy. In the group having additional collaterals, no parameters were changed after sclerotherapy. Conclusion: we demonstrate that HH15, LHL15, and ICGR15 are partially influenced by hepatic circulation but are mainly determined by the function of hepatocytes, whereas serum total bile acid is markedly influenced by hepatic circulation.
Kaoru Iwata; Hiroshi Shijo; Seiichiro Kamimura; Yuko Uehara; Yuji Kitamura; Takeshi Iida; Yasuhiro Okada; Nobuo Akiyoshi; Hiroshi Watanabe; Shotaro Sakisaka
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Publication Detail:
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  22     ISSN:  -     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-Jan-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  45-51     Citation Subset:  -    
Department of Internal Medicine, Fukuoka Red Cross Hospital, Fukuoka, Japan
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