| Effects of esmolol on 35 GHz microwave-induced lethal heat stress. | |
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MedLine Citation:
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PMID: 9278776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The purpose of this study was to examine effects of the beta(1)-adrenoreceptor antagonist esmolol (infused at 2 or 4 mg kg-1 body wt min-1) on heart rate, blood pressure, respiratory rate, localized body temperature changes, survival times, and lethal body temperatures that occur during the exposure of anaesthetized rats to 35 GHz microwaves. 2. Forty Sprague-Dawley rats, anaesthetized with ketamine, were exposed to 35 GHz microwaves at a level that resulted in heating and death. During irradiation, a continuous increase in heart rate and a biphasic response in blood pressure (initial increase followed by a decrease) were observed in all groups of animals. 3. Esmolol caused a significant dose-dependent decrease in blood pressure, relative to saline-treated animals, but only a small attenuation of the heat-induced rise in heart rate. In experiments in which esmolol was infused and microwave exposure was continued until death, drug-treated animals survived for significantly shorter periods and died at significantly lower body temperatures. The change in survival may have been related to the lower blood pressure due to esmolol treatment. |
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Authors:
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J R Jauchem; K L Ryan; J D Lovelace; M R Frei |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of autonomic pharmacology Volume: 17 ISSN: 0144-1795 ISO Abbreviation: J Auton Pharmacol Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-10-20 Completed Date: 1997-10-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8106455 Medline TA: J Auton Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 165-73 Citation Subset: IM |
Affiliation:
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Biological Effects Branch, US Air Force Armstrong Laboratory, Brooks Air Force Base, TX 78235-5324, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Animals Blood Pressure / drug effects Body Temperature / drug effects Heart Rate / drug effects Hot Temperature Male Microwaves / adverse effects* Propanolamines / pharmacology* Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta-1 / antagonists & inhibitors Respiration / drug effects Stress, Physiological / etiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 0/Receptors, Adrenergic, beta-1; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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