| Effects of escin mixture from the seeds of Aesculus hippocastanum on obesity in mice fed a high fat diet. | |
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MedLine Citation:
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PMID: 20645808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Escins, a triterpene glycoside mixture obtained from the ethanol extract of Aesculus hippocastanum L. (Hippocastanaceae) seed, was evaluated for its in vivo effects on the plasma levels of some hormones (leptin, insulin, FT(3), FT(4)) and biochemical parameters (glucose, triglyceride, total cholesterol, HDL-C, LDL-C concentrations) in mice fed with a high fat diet for 5 weeks. A high fat diet induced a remarkable increment in the plasma leptin (p <0.01), total cholesterol (p <0.01) and LDL-C (p <0.001) concentrations compared to control group animals. Combined administration of a high-fat diet with escins decreased leptin (31.6%) (p<0.05) and FT(4) (36.0%) (p<0.05) levels, increased HDL-C concentration (17.0%), while remained ineffective on LDL-C concentration in mice. Results have shown that escins may have beneficial effects in the understanding of obesity. |
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Authors:
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Gülcan Avci; Ismail Küçükkurt; Esra Küpeli Akkol; Erdem Yeşilada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmaceutical biology Volume: 48 ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: England |
Other Details:
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Languages: eng Pagination: 247-52 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aesculus
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chemistry* Animals Anti-Obesity Agents / isolation & purification, therapeutic use* Blood Glucose / analysis Body Weight / drug effects Cholesterol / blood Dietary Fats / administration & dosage* Escin / isolation & purification, therapeutic use* Insulin / blood Leptin / blood Lipids / blood Lipoproteins / blood Male Medicine, Traditional Mice Obesity / blood, prevention & control* Phytotherapy* Plant Extracts / isolation & purification, therapeutic use Seeds / chemistry* Thyroid Hormones / blood Time Factors Turkey |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Blood Glucose; 0/Dietary Fats; 0/Leptin; 0/Lipids; 0/Lipoproteins; 0/Plant Extracts; 0/Thyroid Hormones; 0/lipoprotein cholesterol; 11061-68-0/Insulin; 57-88-5/Cholesterol; 6805-41-0/Escin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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