Document Detail


Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodelling after myocardial infarction.
MedLine Citation:
PMID:  15797934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the effects of eplerenone, a selective aldosterone blocker, on cardiac function after myocardial infarction (MI) and myocardial remodelling related transcriptional factors and mRNA expression in non-infarcted myocardium.
METHODS: MI was induced by ligation of the coronary artery in Wistar rats. Rats were randomly assigned to a vehicle treated group or an eplerenone treated group (100 mg/kg/day).
RESULTS: At four weeks after MI, left ventricular (LV) end diastolic pressure, LV weight, and LV end diastolic dimension were increased in MI rats. Eplerenone significantly reduced the increase in LV end diastolic pressure, LV weight, and LV end diastolic dimension. In the MI rats the decreased ejection fraction indicated systolic dysfunction and the increased E wave to A wave ratio and E deceleration rate indicated diastolic dysfunction. Eplerenone significantly attenuated this systolic and diastolic dysfunction. Myocardial interstitial fibrosis, transcriptional activities of activator protein 1 and nuclear factor kappaB, and mRNA expression of monocyte chemoattractant protein 1, plasminogen activator inhibitor 1, atrial natriuretic peptide, brain natriuretic peptide, and collagen types I and III were significantly increased at four weeks after MI. Eplerenone significantly attenuated interstitial fibrosis and suppressed transcriptional activity and mRNA expression of these genes.
CONCLUSIONS: When administered after MI, eplerenone prevents cardiac remodelling accompanied by systolic and diastolic dysfunction and inhibits abnormal myocardial transcriptional activities and gene expression.
Authors:
S Enomoto; M Yoshiyama; T Omura; R Matsumoto; T Kusuyama; S Kim; Y Izumi; K Akioka; H Iwao; K Takeuchi; J Yoshikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-29
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  91     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-01-18     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1595-600     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Blotting, Northern
Body Weight / drug effects
Coronary Vessels
Echocardiography, Doppler
Heart / drug effects
Heart Ventricles
Ligation / methods
Male
Mineralocorticoid Receptor Antagonists / pharmacology*
Myocardial Infarction / metabolism*
Organ Size
RNA, Messenger / metabolism*
Random Allocation
Rats
Rats, Wistar
Spironolactone / analogs & derivatives*,  pharmacology
Transcription Factors / drug effects,  genetics*
Ventricular Remodeling / drug effects*
Chemical
Reg. No./Substance:
0/Mineralocorticoid Receptor Antagonists; 0/RNA, Messenger; 0/Transcription Factors; 27O7W4T232/Spironolactone; 6995V82D0B/eplerenone
Comments/Corrections

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