Document Detail

Effects of epinephrine on hemodynamics and oxygen metabolism in dopamine-resistant septic shock.
MedLine Citation:
PMID:  2209154     Owner:  NLM     Status:  MEDLINE    
The hemodynamic effects of epinephrine were prospectively studied in 13 patients with septic shock who remained hypotensive after both fluid loading and dopamine. Hemodynamic measurements were performed before and one hour after the start of epinephrine infusion. Systolic, diastolic, and mean arterial pressure increased in all patients (p less than 0.01). Cardiac index and systemic vascular resistance increased by 34 and 32 percent, respectively (p less than 0.05), but heart rate and pulmonary vascular resistance remained unchanged. There was a concomitant increase in oxygen delivery (p less than 0.01) and oxygen consumption (p less than 0.05), the magnitude of the latter being related to baseline lactacidemia (p less than 0.01). In view of the generally recognized physiologic goals of septic shock management, we conclude that epinephrine could be an appropriate alternative where fluid loading and dopamine have failed.
P E Bollaert; P Bauer; G Audibert; H Lambert; A Larcan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  98     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-15     Completed Date:  1990-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  949-53     Citation Subset:  AIM; IM    
Service de Reanimation Médicale, Centre Hospitalier Regional et Universitaire, Nancy, France.
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MeSH Terms
Blood Pressure / drug effects
Dopamine / therapeutic use*
Epinephrine / therapeutic use*
Fluid Therapy
Hemodynamics / drug effects*
Lactates / blood
Lactic Acid
Middle Aged
Oxygen Consumption / drug effects*
Prospective Studies
Shock, Septic / drug therapy,  metabolism,  physiopathology*,  therapy
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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