Document Detail

Effects of epinephrine on the cardiorespiratory response to hypoxia in sedated newborn piglets with intact and denervated carotid bodies.
MedLine Citation:
PMID:  7662815     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the effects of epinephrine on the cardiorespiratory response to hypoxia in the neonate, 35 sedated, spontaneously breathing newborn piglets (mean +/- SD, age 5 +/- 0.8 days; weight 1.6 +/- 0.3 kg) with intact (ICB) or denervated (DCB) carotid bodies were studied before and during an infusion of saline or epinephrine (2.2 +/- 1.0 microgram/kg/min, i.v.). Cardiorespiratory measurements were performed while the animals breathed room air and after 10 min of hypoxia (FiO2 0.10) during saline or epinephrine infusion. During epinephrine infusion, the ICB animals had a sustained increase in minute ventilation during hypoxia while the control group showed a biphasic ventilatory response with depression during sustained hypoxia. After the chemodenervation, the ventilatory response to hypoxia was completely blunted in saline and epinephrine animals. In the ICB and DCB animals, the arterial blood pressure decreased significantly with hypoxia during epinephrine infusion, while cardiac output increased significantly in all ICB and DCB saline animals. The oxygen consumption (VO2) decreased significantly after 10 min of hypoxia in all groups except in the ICB epinephrine animals, in whom the VO2 did not change with hypoxia. In conclusion, the administration of epinephrine to newborn piglets reverses the depressed ventilatory response to hypoxia and this effect requires the activity of the peripheral chemoreceptors.
C Suguihara; D Hehre; E Bancalari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  67     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-12     Completed Date:  1995-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  352-9     Citation Subset:  IM    
Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA.
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MeSH Terms
Animals, Newborn / physiology*
Anoxia / physiopathology*
Blood Pressure
Cardiac Output
Carotid Body / physiology*
Epinephrine / pharmacology*
Heart / physiopathology*
Hydrogen-Ion Concentration
Oxygen Consumption
Respiration / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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