Document Detail

Effects of epidural morphine and transdermal fentanyl analgesia on physiology and behaviour after abdominal surgery in pigs.
MedLine Citation:
PMID:  16460586     Owner:  NLM     Status:  MEDLINE    
The objective of this work was to evaluate the physiological and behavioural effects of opioid analgesic treatment in pigs subjected to abdominal surgery. Ten Swedish Landrace x Yorkshire pigs (20 +/- 4 kg b.w.) were submitted for intestinal cannulation. The pigs were allocated into two groups during one preoperative, one surgical and two postoperative days. All pigs were anaesthetized with medetomidine, tiletamine and zolazepam. One group was treated with epidural morphine (0.1 mg/kg) preoperatively, and transdermal fentanyl patches (50 microg/kg/h) were applied behind the ear immediately after surgery. The other group received epidural saline (equivalent volume) and placebo patches. All pigs were regularly weighed and clinically examined and repeated blood samples were analysed for serum concentrations of cortisol, beta-endorphin and fentanyl. Pre- and postoperative behaviours were evaluated by a swine specialist blinded to the treatment, three times a day, and were also videotape recorded for a total of 84 h per pig. No differences in behaviour were noted by the observer. During the first postoperative 12 h, treated pigs did not differ in activity compared with preoperative recordings, while untreated pigs were found to be less active. The treated group started to show interest in eating immediately after anaesthesia recovery, whereas the placebo group did not. During the 12-60 h postoperative period, the treated group had lower activity levels compared with the preoperative levels, which were similar to those in the placebo group. Treated pigs gained 0.5 +/- 0.2 kg during the subsequent two postoperative days, whereas the untreated pigs lost weight throughout the experiment. Cortisol concentration differed immediately after the surgery: Group P had 325 +/- 120 nmol/L and Group M 159 +/- 49 nmol/L. beta-endorphin concentration did not differ between groups. The highest serum fentanyl concentration (0.37 +/- 0.3 ng/mL) was measured 24 h postoperatively. Preoperative epidural morphine in combination with postoperative transdermal fentanyl resulted in earlier return to normal activity levels and an immediate weight gain after surgery.
L M Malavasi; G Nyman; H Augustsson; M Jacobson; M Jensen-Waern
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory animals     Volume:  40     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  England    
Other Details:
Languages:  eng     Pagination:  16-27     Citation Subset:  IM    
Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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MeSH Terms
Abdomen / surgery
Adjuvants, Anesthesia / pharmacology*
Administration, Cutaneous
Analgesics, Opioid / pharmacology*
Anesthesia, Epidural / veterinary*
Behavior, Animal / drug effects*
Feeding Behavior / drug effects,  physiology
Fentanyl / blood,  pharmacology*
Hydrocortisone / blood
Hypnotics and Sedatives
Morphine / pharmacology*
Motor Activity / drug effects,  physiology
Pain Measurement / veterinary
Surgery, Veterinary / methods*
beta-Endorphin / blood
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Analgesics, Opioid; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 50-23-7/Hydrocortisone; 57-27-2/Morphine; 60617-12-1/beta-Endorphin

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