Document Detail


Effects of epidural anesthesia during labor on maternal plasma beta-endorphin levels.
MedLine Citation:
PMID:  6305238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma beta-endorphin (beta-EP) was measured in 48 women. Twenty-three were in labor. In 13 of the 23 patients in labor, beta-EP was determined prior to and after complete onset of epidural anesthesia, and in 10 women, who served as controls, prior to and after injection of saline into the epidural space as part of the loss of resistance technique, but before injection of the local anesthetic. Venous blood also was obtained for plasma beta-EP determinations from 10 healthy non-pregnant women and from 15 patients scheduled for elective repeat cesarean section and who were not in labor. Human beta-EP was determined by radioimmunoassay following silicic acid extraction of plasma samples and separation of the beta-EP fraction by gel chromatography. In the 10 non-pregnant volunteers, plasma beta-EP averaged 11.3 +/- 1.5 fmol/ml (mean +/- SE) as compared with 43.7 +/- 6.5 fmol/ml observed in the 15 women with term pregnancies who were not in labor (P less than 0.005). In the 13 patients in labor who underwent epidural anesthesia, plasma beta-EP concentrations decreased (P less than 0.005) from 54.5 +/- 9.0 to 28.2 +/- 3.5 fmol/ml, whereas there was no significant change in plasma beta-EP levels in the 10 controls who averaged 64 +/- 20.5 and 55.8 +/- 13.6 fmol/ml prior to and following saline injection. These data confirm that plasma beta-EP levels are significantly higher in women with term pregnancies in labor than in non-pregnant women and also demonstrate that epidural anesthesia during labor is accompanied by a significant decrease in maternal plasma beta-EP concentrations.
Authors:
T K Abboud; F Sarkis; T T Hung; S S Khoo; L Varakian; E Henriksen; R Noueihed; U Goebelsmann
Related Documents :
6268998 - Vasopressin stimulates release of beta-lipotropin and beta-endorphin in conscious rats ...
8062498 - The effect of age on the beta-adrenergic lipolytic response in healthy humans.
17902948 - Poloidal beta and internal inductance measurement on ht-7 superconducting tokamak.
1378128 - Desensitization of beta-adrenoceptor- and prostaglandin e1 receptor-mediated human vasc...
9748428 - Inhaled corticosteroid therapy reduces the early morning peak in cortisol and aldosterone.
3712418 - A rapid method for monocyte isolation and chemotaxis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  59     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aging
Anesthesia, Epidural*
Anesthesia, Obstetrical*
Cesarean Section
Endorphins / blood*
Female
Humans
Labor, Obstetric*
Parity
Pregnancy
beta-Endorphin
Chemical
Reg. No./Substance:
0/Endorphins; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human sperm motility--enhancement and inhibition measured by laser Doppler spectroscopy.
Next Document:  Effect of endotoxin on mouse serum angiotensin-converting enzyme.