Document Detail

Effects of epidural anesthesia and analgesia on coagulation and outcome after major vascular surgery.
MedLine Citation:
PMID:  1952169     Owner:  NLM     Status:  MEDLINE    
To examine the interaction of epidural anesthesia, coagulation status, and outcome after lower extremity revascularization, 80 patients with atherosclerotic vascular disease were prospectively randomized to receive general anesthesia combined with postoperative epidural analgesia (GEN-EPI) or general anesthesia with on-demand narcotic analgesia (GEN). Demographics did not differ between groups except that the GEN-EPI group had a higher incidence of diabetes mellitus and of previous myocardial infarction. Coagulation status was monitored using thromboelastography. An additional 40 randomly selected patients without atherosclerotic vascular disease undergoing noncardiovascular procedures served as controls for coagulation status. Vascular surgical patients were hypercoagulable compared with control patients before operation and on the first postoperative day. Postoperatively, this hypercoagulability was attenuated in the GEN-EPI group and was associated with a lower incidence of thrombotic events (peripheral arterial graft coronary artery or deep vein thromboses). The rates of cardiovascular, infectious, and overall postoperative complications, as well as duration of intensive care unit stay, were significantly reduced in the GEN-EPI group. Stepwise logistic regression demonstrated that the only significant predictors of postoperative cardiovascular complications were preoperative congestive heart failure and general anesthesia without epidural analgesia. We conclude that in patients with atherosclerotic vascular disease undergoing arterial reconstructive surgery (a) thromboelastographic evidence of increased platelet-fibrinogen interaction is associated with early postoperative thrombotic events, and (b) epidural anesthesia and analgesia is associated with beneficial effects on coagulation status and postoperative outcome compared with intermittent on-demand opioid analgesia.
K J Tuman; R J McCarthy; R J March; G A DeLaria; R V Patel; A D Ivankovich
Related Documents :
9836029 - Postoperative patient-controlled epidural analgesia with opioid bupivacaine mixtures.
8604459 - Intrathecal infusion systems for treatment of chronic low back and leg pain of noncance...
16651569 - Efficacy of periarticular multimodal drug injection in total knee arthroplasty. a rando...
12607119 - Prospective trial comparing bilateral and unilateral varicose vein surgery.
1750589 - Pain following thoracotomy. a randomised, double-blind comparison of lumbar versus thor...
15110369 - Bacterial contamination of epidural catheters: microbiological examination of 502 epidu...
24788619 - Randomised comparison of initial triple dmard therapy with methotrexate monotherapy in ...
15539849 - Transurethral prostatectomy and inguinal hernia repair in a single session.
18813069 - Sensitivity change in cornea and tear layer due to incision difference on cataract surg...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  73     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1991-12-26     Completed Date:  1991-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  696-704     Citation Subset:  AIM; IM    
Department of Anesthesiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analgesia, Epidural*
Anesthesia, Epidural*
Blood Coagulation
Middle Aged
Pain, Postoperative / drug therapy*
Postoperative Complications / etiology*
Risk Factors
Vascular Surgical Procedures*
Comment In:
Anesth Analg. 1992 Jul;75(1):141-2   [PMID:  1530729 ]
Anesth Analg. 1992 Sep;75(3):463-4   [PMID:  1510275 ]
Anesth Analg. 1991 Dec;73(6):683-5   [PMID:  1952166 ]
Anesth Analg. 1992 Sep;75(3):464-7   [PMID:  1342785 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of adenosine on myocardial blood flow and metabolism after coronary artery bypass surgery.
Next Document:  Transesophageal Doppler cardiac output monitoring: performance during aortic reconstructive surgery.