Document Detail

Effects of ephedrine on oxygen consumption and cardiac output.
MedLine Citation:
PMID:  8607315     Owner:  NLM     Status:  MEDLINE    
Bolus doses of ephedrine are often used by anaesthesiologists for intraoperative hypotension. This randomized single-blind cross-over study was designed to simultaneously evaluate circulatory, respiratory and metabolic effects of intravenously given ephedrine in 12 healthy male volunteers. Oxygen uptake and carbon dioxide excretion were measured with indirect calorimetry and non-invasive transthoracic electrical bioimpedance was used for cardiac output measurements. The maximum effect on most variables was reached at 4-5 min. At 5 min after the administration of ephedrine 0.1 mg per kilogram body weight, there were significant increases in cardiac index, systolic and mean arterial blood pressure, expired minute volume, oxygen uptake and carbon dioxide excretion rates. There were no significant changes in the quotient between oxygen uptake rate and cardiac index, VO2/CI during the 30 min study period. The O2 saturation was not altered. The present study indicates that ephedrine increases oxygen demand and supply in a similar magnitude.
M Rådström; J Bengtsson; S Ederberg; A Bengtsson; A C Loswick; J P Bengtson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  39     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-05-23     Completed Date:  1996-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1084-7     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Sahlgren University Hospital, Göteborg University, Sweden.
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MeSH Terms
Adrenergic Agents / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects*
Cross-Over Studies
Ephedrine / pharmacology*
Oxygen Consumption / drug effects*
Single-Blind Method
Reg. No./Substance:
0/Adrenergic Agents; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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