Document Detail


Effects of environmental tobacco smoke on the developing immune system of infant monkeys.
MedLine Citation:
PMID:  17482667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exposure to environmental tobacco smoke (ETS) is associated with an increased incidence of allergic and infectious diseases among children that is thought to be partly due to the immaturity of the immune system. OBJECTIVE: We sought to investigate the effects of ETS exposure on immune development during the first year of life in the nonhuman primate. METHODS: Fifteen neonatal rhesus monkeys studied to 13 months of postnatal age were randomized into 3 groups: (1) exposure to filtered air, (2) continuous ETS exposure beginning at gestation day 50 (perinatal ETS); and (3) exposure to ETS beginning at 6 months of age (6-month ETS). Complete blood counts, lymphocyte subsets, and mRNA levels of 12 cytokines in PBMCs were measured. RESULTS: Fetal/infant exposure to ETS altered the normal maturation of mRNA levels of IFN-gamma, IL-2, and IL-10, as well as the ratio of CD4 to CD8 lymphocytes, compared with filtered-air control levels. Blood lymphocyte subset distribution also significantly differed based on the onset of exposure to ETS. Subacute exposure to ETS for 2 weeks in 6-month-old infants was found to increase levels of peripheral blood neutrophils and IL-6 mRNA. CONCLUSIONS: Short-term exposure to ETS can induce an acute systemic inflammatory response in the neonatal nonhuman primate, and long-term exposure to ETS beginning in utero or at 6 months of postnatal age can significantly alter immune effectors. CLINICAL IMPLICATIONS: Normal immune system development is compromised by in utero and postnatal exposure to ETS and might contribute to ETS-related childhood diseases.
Authors:
Lei Wang; Jesse P Joad; Kristina Abel; Abigail Spinner; Suzette Smiley-Jewell; Hao Liu; Kent E Pinkerton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-05-07
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  120     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-27     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-51     Citation Subset:  AIM; IM    
Affiliation:
Center for Health and the Environment,University of California, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / blood,  metabolism
Animals
Animals, Newborn / growth & development*
Cytokines / genetics
Embryonic Development
Immune System / embryology*,  growth & development*
Leukocyte Count
Lymphocyte Subsets
Macaca mulatta
Monocytes / metabolism
RNA, Messenger / metabolism
Tobacco Smoke Pollution*
Grant Support
ID/Acronym/Agency:
ES05707/ES/NIEHS NIH HHS; P51 RR00169/RR/NCRR NIH HHS; R01 ES011634/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/RNA, Messenger; 0/Tobacco Smoke Pollution

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