| Effects of endurance training on lactate removal by oxidation and gluconeogenesis during exercise. | |
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MedLine Citation:
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PMID: 8594549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes the effects of 9 weeks of endurance-training on the relative rates of lactate removal via oxidation and gluconeogenesis in humans. Before and after training, eight subjects performed incremental (60 W plus 40 W every 6 min) exercise tests, while 14C-lactate was infused into one forearm vein and arterialized venous blood was sampled from the other forearm. During the trial, the volume of expired 14CO2 and circulating 14C-lactate and 14C-glucose specific radioactivities were measured. Such measurements revealed that training increased the estimated oxidation of equivalent venous blood lactate concentrations [VLa] of greater than 1.6 mmol/l. These increases in lactate oxidation were more than would be predicted from the approximately 40% higher O2 uptake values at any [VLa] after training. At a [VLa] of 6 mmol/l, rates of lactate oxidation were increased by some 100% following training, from 105 +/- 12 to 208 +/- 33 micromol/min/kg (P < 0.01). Improvements in lactate oxidation after training reduced the estimated rates of lactate-to-glucose conversion from 40 +/- 3 to 9 +/- 2 micromol/min/kg at a [VLa] of 2.5 mmol/l (P < 0.01). Thus, unlike in rats, human endurance-training does not increase gluconeogenesis. In the final stages of progressive exercise after training, more than 80% of lactate was oxidised and accounted for approximately 45% of overall carbohydrate oxidation. |
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Authors:
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H H MacRae; T D Noakes; S C Dennis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 430 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-04-09 Completed Date: 1996-04-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 964-70 Citation Subset: IM |
Affiliation:
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Medical Research Council Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory 7925, South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbohydrate Metabolism Gluconeogenesis* Humans Lactates / blood* Lactic Acid Male Oxidation-Reduction Physical Endurance / physiology Physical Exertion / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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