Document Detail


Effects of endurance training on extrarenal potassium regulation and exercise performance in patients on haemodialysis.
MedLine Citation:
PMID:  19389866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Haemodialysis patients (HDP) with anaemia display impaired plasma K(+) regulation during exercise and poor exercise performance. Epoetin treatment and exercise training improve exercise performance in HDP, but whether this is associated with improved K(+) regulation is unknown. METHODS: Six HDP with near-normal [Hb] were tested for aerobic power ( ) and plasma [K(+)] during incremental exercise; quadriceps muscle strength (peak torque, PT) from 0 to 360 degrees s(-1) and fatiguability (decline in strength during thirty contractions). Tests were conducted at baseline, after 6 weeks of normal activity (pre-train) and following 6 weeks cycle training (post-train). Six healthy untrained controls (CON) matched for age, sex, mass and height were tested at baseline. RESULTS: In HDP at baseline, and PT from 0 to 360 degrees s(-1) were respectively reduced by 37% and 27-42%, compared to CON (P < 0.05). Plasma [K(+)], the rise in [K(+)] (Delta[K(+)]) and the Delta[K(+)] relative to total work done (Delta[K(+)] work(-1) ratio) during incremental exercise were all higher in HDP at baseline compared to CON (P < 0.05). Exercise training increased time to fatigue by 12% (P < 0.05) but did not improve K(+) regulation or . An inverse correlation was found between the Delta[K(+)] work(-1) ratio and for pooled CON and HDP data. CONCLUSIONS: In HDP treated with epoetin, poor exercise performance was related to impaired extrarenal K(+) regulation, whilst training improved exercise performance but not K(+) regulation. Thus, although impaired extrarenal K(+) regulation may contribute to poor exercise performance in HDP, exercise performance can still improve with training despite unchanged K(+) regulation.
Authors:
Aaron C Petersen; Murray J Leikis; Lawrence P McMahon; Annette B Kent; Michael J McKenna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-23
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  24     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  2882-8     Citation Subset:  IM    
Affiliation:
Centre for Ageing, Rehabilitation, Exercise and Sport, Victoria University, Melbourne, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / drug therapy,  etiology,  physiopathology
Case-Control Studies
Erythropoietin, Recombinant / therapeutic use
Exercise / physiology*
Exercise Test
Exercise Therapy
Female
Humans
Kidney Failure, Chronic / blood,  physiopathology,  therapy
Male
Middle Aged
Muscle Fatigue / physiology
Muscle Strength / physiology
Oxygen Consumption
Physical Endurance / physiology*
Potassium / blood*
Renal Dialysis* / adverse effects
Chemical
Reg. No./Substance:
0/Erythropoietin, Recombinant; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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